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Cited 9 time in webofscience Cited 11 time in scopus
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Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease

Authors
Lee, Jae MinKeum, BoraYoo, In KyungKim, Seung HanChoi, Hyuk SoonKim, Eun SunSeo, Yeon SeokJeen, Yoon TaeChun, Hoon JaiLee, Hong SikUm, Soon HoKim, Chang DuckKim, Myung GyuJo, Sang Kyung
Issue Date
Sep-2016
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
ascorbic acid; chronic kidney disease; colonoscopy; polyethylene glycol; safety
Citation
MEDICINE, v.95, no.36
Indexed
SCIE
SCOPUS
Journal Title
MEDICINE
Volume
95
Number
36
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6109
DOI
10.1097/MD.0000000000004755
ISSN
0025-7974
Abstract
The safety of polyethylene glycol plus ascorbic acid has not been fully investigated in patients with renal insufficiency. High-dose ascorbic acid could induce hyperoxaluria, thereby causing tubule-interstitial nephritis and renal failure. This study aims to evaluate the safety and efficacy of polyethylene glycol plus ascorbic acid in patients with chronic kidney disease.We retrospectively reviewed prospectively collected data on colonoscopy in patients with impaired renal function. Patients were divided into 2 groups: 2 L polyethylene glycol plus ascorbic acid (n = 61) and 4 L polyethylene glycol (n = 80). The safety of the 2 groups was compared by assessing the differences in laboratory findings before and after bowel cleansing.The laboratory findings were not significantly different before and after the administration of 2 L polyethylene glycol plus ascorbic acid or 4 L polyethylene glycol. In both groups, the estimated glomerular filtration rate was not influenced by the administration of the bowel-cleansing agent. Patients' reports on tolerance and acceptability were better in the 2 L polyethylene glycol plus ascorbic acid group than in the 4 L polyethylene glycol group.The 2 L polyethylene glycol plus ascorbic acid solution is a safe choice for bowel preparation before colonoscopy in patients with impaired renal function.
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2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Kim, Eun Sun
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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