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Eradication Rates of Helicobacter pylori in Korea Over the Past 10 years and Correlation of the Amount of Antibiotics Use: Nationwide Survey

Authors
Shin, Woon GeonLee, Sang WooBaik, Gwang HoHuh, Kyu ChanLee, Sang InChung, Jun-WonJung, Woon TaePark, Moo InJung, Hye-kyungKim, Heung UpKim, Jeong HwanSeol, Sang YoungYoon, Soon ManJeon, Seong WooHong, Su JinKim, Gwang HaLee, Dong HoKim, Hyun SooChoi, Suck CheiKang, Hee MoLee, JoongyubKim, Jae GyuKim, Jae J.
Issue Date
Aug-2016
Publisher
WILEY
Keywords
Helicobacter pylori; treatment failure; trends; antibiotics
Citation
HELICOBACTER, v.21, no.4, pp.266 - 278
Indexed
SCIE
SCOPUS
Journal Title
HELICOBACTER
Volume
21
Number
4
Start Page
266
End Page
278
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6221
DOI
10.1111/hel.12279
ISSN
1083-4389
Abstract
BackgroundThe efficacy of proton-pump inhibitor-amoxicillin-clarithromycin therapy for H. pylori eradication has decreased over time. ObjectiveWe assessed the trend of H. pylori eradication rates over the last 10 years and the relationship between the eradication rates and the amount of macrolide antibiotic use in a country with a high prevalence of H. pylori infection. MethodsThis vast nationwide multicenter study was conducted with 34,139 adults treated for H. pylori infection from January 2001 to December 2010. The defined daily dose per km(2) (DSD) of macrolide antibiotics was calculated (n = 141,019) using the Health Insurance Review & Assessment data base from 2008 to 2010 in the two cities which had the lowest (Jeju city) or highest (Chuncheon city) eradication rate. ResultsThe eradication rates of proton-pump inhibitor-amoxicillin-clarithromycin therapy ranged 84.9-87.5% from 2001 to 2007, and those of 2008 to 2010 ranged 80.0-81.4% with a decreasing trend (p < 0.0001). The decreasing trend of eradication rates for the overall first-line therapy was observed only in three of the seven geographic areas in Korea (p < 0.0001). The DSD of macrolide antibiotics was significantly higher in Jeju than Cheunchon city (0.85 vs 0.52, p < 0.0001). ConclusionsH. pylori eradication rates with clarithromycin-containing triple therapy in Korea showed a decreasing trend over the past 10 years, although the trend varied among geographic areas. This difference may be associated with the amount of macrolide antibiotic use.
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Lee, Sang Woo
안산병원 (Department of Gastroenterology and Hepatology, Ansan Hospital)
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