Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea
- Chung, Sook Hee; Park, Sang Un; Cheon, Jae Hee; Kim, Eun Ran; Byeon, Jeong-Sik; Ye, Byong Duk; Keum, Bora; Shim, Ki-Nam; Jung, Sung-Ae; Kim, Jin-Oh; Jeon, Seong Ran; Song, Hyun Joo; Moon, Jeong Seop; Chang, Dong Kyung
- Issue Date
- Cryptogenic multifocal ulcerous stenosing enteritis; Diagnosis; Characteristics; Treatment outcome
- DIGESTIVE DISEASES AND SCIENCES, v.60, no.9, pp.2740 - 2745
- Journal Title
- DIGESTIVE DISEASES AND SCIENCES
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- End Page
- Background Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease that is characterized by multiple, recurring small intestinal ulcers with stenosis of unknown causes. The aim of this study was to investigate the clinical characteristics and the treatment outcomes of patients with CMUSE in Korea. Methods We performed a multicenter study to retrospectively analyze clinical data from 20 patients who suffered from CMUSE between 1984 and 2012. Their clinical characteristics and long-term disease courses were investigated. Results The most common initial symptom of CMUSE was abdominal pain (14/20, 70 %). Small bowel series (13/20, 65 %), double-balloon enteroscopy (12/20, 60 %), CT enterography (12/20, 60 %), and capsule endoscopy (10/20, 50 %) were used to diagnose CMUSE. The strictures of the patients were located in the jejunum (5/20, 25 %), ileum (7/20, 35 %), and both jejunum and ileum (6/20, 30 %). The number of patients in a state of remission, persistent disease, and relapse at the end of follow-up were 13/20 (65 %), 2/20 (10 %), and 5/20 (25 %), respectively. The median relapse-free survival was of 67.1 months. Seventy-five percent relapse-free survivals for female and male patients were 93 and 9 months, respectively (P = 0.031). Conclusion CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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