Improvement of medication adherence with simplified once-daily immunosuppressive regimen in stable kidney transplant recipients: A prospective cohort studyopen access
- Authors
- Oh, Chang-Kwon; Bang, Jun Bae; Kim, Sung-Joo; Huh, Kyu Ha; Kim, Soo Jin; Jeon, Jin Seok; Han, Sang Youb; Cho, Hong Rae; Kwon, Young Joo; Lee, Su Hyung; Kim, Yu Seun
- Issue Date
- Jun-2020
- Publisher
- ELSEVIER SINGAPORE PTE LTD
- Keywords
- Medication adherence; Kidney transplantation; Immunosuppression; Tacrolimus
- Citation
- Asian Journal of Surgery, v.43, no.6, pp 660 - 667
- Pages
- 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- Asian Journal of Surgery
- Volume
- 43
- Number
- 6
- Start Page
- 660
- End Page
- 667
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/789
- DOI
- 10.1016/j.asjsur.2019.07.011
- ISSN
- 1015-9584
0219-3108
- Abstract
- Background
Many immunosuppressive drugs are prescribed as twice-daily dosing. A simplified once-daily dosing of immunosuppressive drug regimen may improve medication adherence. We investigated medication adherence of simplified once-daily immunosuppressive regimen consisting of extended-release tacrolimus, sirolimus, and corticosteroids along with the efficacy and safety of this regimen.
Methods
This study was a prospective, multicenter, controlled and cohort trial. Stable kidney transplant recipients who had received transplantation at least 3 months before the study enrollment were eligible for the study. Participants were required to fill-out the self-reported immunosuppressant therapy barrier scale (ITBS) questionnaire before and after the conversion. Other clinical laboratory parameters and adverse events were evaluated until 6 months post-conversion.
Results
A total of 160 kidney recipients comprised the intention-to-treat population. The mean total ITBS score was 19.5 ± 4.0 at pre-conversion and 6 months after converting, the mean total ITBS score was 16.6 ± 3.6 (p < 0.001). Particularly, the ITBS scores of 4 questions related to the frequency of medication dosing were significantly different between pre-conversion and post-conversion. Only 1 patient (0.62%) was diagnosed as biopsy-confirmed acute rejection in the study period. There was no significant change in the mean estimated glomerular filtration rate after the conversion. Overall 95 patients (59.4%) had an adverse event and 28 patients (17.5%) had a serious adverse event. No graft loss and 1 death were reported.
Conclusion
Medication adherence after the conversion to the once-daily immunosuppressive regimen was significantly improved with no additional risks of efficacy failure or adverse events.
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- Appears in
Collections - 2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles
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