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Cited 15 time in webofscience Cited 16 time in scopus
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The Influence of Alcoholic Liver Disease on Serum PIVKA-II Levels in Patients without Hepatocellular Carcinoma

Authors
Kang, KeunheeKim, Ji HoonKang, Seong HeeLee, Beom JaeSeo, Yeon SeokYim, Hyung JoonYeon, Jong EunPark, Jong-JaeKim, Jae SeonBak, Young-TaeByun, Kwan Soo
Issue Date
Mar-2015
Publisher
거트앤리버 발행위원회
Keywords
Prothrombin induced by vitamin K deficiency or antagonist II; Liver diseases; alcoholic; Hepatocellular carcinoma
Citation
Gut and Liver, v.9, no.2, pp 224 - 230
Pages
7
Indexed
SCIE
SCOPUS
KCI
Journal Title
Gut and Liver
Volume
9
Number
2
Start Page
224
End Page
230
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8131
DOI
10.5009/gnl14047
ISSN
1976-2283
2005-1212
Abstract
Background/Aims Prothrombin induced by vitamin K deficiency or antagonist II (PIVKA-II) is a widely used diagnostic marker for hepatocellular carcinoma (HCC). We evaluated the correlation between alcoholic liver disease (ALD) and serum PIVKA-II levels in chronic liver disease (CLD) patients. Methods We retrospectively reviewed the medical records of 2,528 CLD patients without HCC. Among these patients, 76 exhibited serum high PIVKA-II levels of >125 mAU/mL (group 1). We categorized 76 control patients matched by age, sex, and the presence of liver cirrhosis from the remaining patients who were negative for serum PIVKA-II (group 2). Results Group 1 revealed increased antibiotic usage (23.7% vs 2.6%, p<0.001) and incidence of ALD (60.5% vs 14.5%, p<0.001) as well as elevated aspartate aminotransferase (52.5 IU/L vs 30.5 IU/L, p=0.025) and γ glutamyl transpeptidase (67.5 IU/L vs 36.5 IU/L, p=0.005) levels compared with group 2. Further, group 1 was significantly associated with a worse Child-Pugh class than group 2. In the multivariate analysis, ALD (odds ratio [OR], 7.151; p<0.001) and antibiotic usage (OR, 5.846; p<0.001) were significantly associated with positive PIVKA-II levels. Conclusions Our study suggests that ALD and antibiotics usage may be confounding factors when interpreting high serum PIVKA-II levels in patients without HCC. Therefore, serum PIVKA-II levels in patients with ALD or in patients administered antibiotics should be interpreted with caution.
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Park, Jong Jae
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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