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Cited 10 time in webofscience Cited 11 time in scopus
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Rare case of pancreatic cancer with leptomeningeal carcinomatosis

Authors
Yoo, In KyungLee, Hong SikKim, Chang DukChun, Hoon JaiJeen, Yoon TaeKeum, BoraKim, Eun SunChoi, Hyuk SoonLee, Jae MinKim, Seung HanNam, Seung JooHyun, Jong Jin
Issue Date
21-Jan-2015
Publisher
BAISHIDENG PUBLISHING GROUP INC
Keywords
Pancreatic cancer; Radiation therapy; Tumor marker; Leptomeningeal carcinomatosis; Prognosis
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, v.21, no.3, pp 1020 - 1023
Pages
4
Indexed
SCIE
SCOPUS
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
Volume
21
Number
3
Start Page
1020
End Page
1023
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8215
DOI
10.3748/wjg.v21.i3.1020
ISSN
1007-9327
2219-2840
Abstract
Leptomeningeal carcinomatosis occurs very rarely in patients with pancreatic cancer. Leptomeningeal carcinomatosis is characterized by multifocal seeding of the leptomeninges by malignant cells that originate from a solid tumor. To the best of our knowledge, brain metastasis from pancreatic cancer is extremely rare. Leptomeningeal carcinomatosis is estimated to occur in 3% to 8% of cases of solid tumors. The clinical manifestation usually involves neurological symptoms, including dizziness, headache, vomiting, nausea, and hemiparesis, symptoms similar to those of meningitis or brain tumors. Diagnostic methods for leptomeningeal carcinomatosis include brain magnetic resonance imaging and cerebrospinal fluid examination. Here, we describe a case of leptomeningeal carcinomatosis in which the primary tumor was later determined to be pancreatic cancer. Brain magnetic resonance imaging findings showed mild enhancement of the leptomeninges, and cerebrospinal fluid cytology was negative at first. However, after repeated spinal taps, atypical cells were observed on cerebrospinal fluid analysis and levels of tumor markers such as carbohydrate antigen 19-9 in cerebrospinal fluid were elevated. Abdominal computed tomography, performed to determine the presence of extracerebral tumors, revealed pancreatic cancer. Pancreatic cancer was confirmed histopathologically on examination of an endoscopic ultrasound-guided fine needle aspiration specimen.
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