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Cited 16 time in webofscience Cited 17 time in scopus
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Analysis of behavioral changes in zebrafish (Danio rerio) larvae caused by aminoglycoside-induced damage to the lateral line and muscles

Authors
Han, EunjungOh, Kyoung HoPark, SaemiRah, Yoon ChanPark, Hae-ChulKoun, Soon ilChoi, June
Issue Date
May-2020
Publisher
ELSEVIER
Keywords
Behavior; Lateral line; Muscle; Zebrafish; Aminoglycoside
Citation
NeuroToxicology, v.78, pp 134 - 142
Pages
9
Indexed
SCIE
SCOPUS
Journal Title
NeuroToxicology
Volume
78
Start Page
134
End Page
142
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/847
DOI
10.1016/j.neuro.2020.03.005
ISSN
0161-813X
1872-9711
Abstract
Zebrafish behavior is influenced by the lateral line hair cells and muscles. Drug-induced behavioral changes can serve as indicators in the evaluation of drug toxicity. The aminoglycoside family of antibiotics comprise a number of agents, including neomycin (NM) and gentamicin (GM). We hypothesized that NM and GM exert different effects on zebrafish larvae through their action on the lateral line and muscle fibers, inducing different swimming behavioral patterns such as locomotor behavior and the startle response. In this study, 125 mu M NM and 5, 10, 20 mu M GM induced hair cell damage in the anterior and posterior lateral lines of zebrafish larvae. However, unlike GM, 125 mu M NM also caused muscle damage. Locomotor behavior was decreased in the 125 mu M NM-exposed group compared to the group exposed to GM. Furthermore, 125 mu M NM exposure induced significantly different patterns of various indices of startle behavior compared with the GM exposure groups. Additionally, the larvae exhibited different startle responses depending on the concentration of GM. These results suggest that GM may be the drug-of-choice for analyzing behavioral changes in zebrafish caused by damage to the lateral line alone. Our study highlights the importance of confirming muscle damage in behavioral analyses using zebrafish.
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4. Research institute > Zebrafish Translational Medical Research Center > 1. Journal Articles
3. Graduate School > Biomedical Research Center > 1. Journal Articles
2. Clinical Science > Department of Otorhinolaryngology-Head and Neck Surgery > 1. Journal Articles

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Oh, Kyoung Ho
Ansan Hospital (Department of Otorhinolaryngology-Head and Neck Surgery, Ansan Hospital)
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