Detailed Information

Cited 0 time in webofscience Cited 943 time in scopus
Metadata Downloads

A randomized trial of laparoscopic versus open surgery for rectal cancer

Authors
Bonjer H.J.Deijen C.L.Abis G.A.Cuesta M.A.Van Der Pas M.H.G.M.De Lange-De Klerk E.S.M.Lacy A.M.Bemelman W.A.Andersson J.Angenete E.Rosenberg J.Fuerst A.Haglind E.d'Hoore A.Birch D.DeGara C.Jamieson C.Peiman P.Jensen K.J.Bulut O.Jess P.Harvald T.Ovesen H.Lundhus E.Iesalnieks I.Agha A.Jaeger C.Kreis M.Kasparek M.Kim S.H.van der Peet D.Buunen M.Hop W.Neijenhuis P.Coene P.P.van der Harst E.van't Riet Y.Gerhards M.Prins H.Targarona E.Balague C.Martinez C.Osorio J.F.Molina G.Delgado S.Lujan J.Valero G.Alonso-Poza A.Losadar M.Argudo S.Lackberg Z.Skullman S.Kurlberg G.Ekelund J.Kressner U.Matthiessen P.
Issue Date
2015
Publisher
Massachussetts Medical Society
Citation
New England Journal of Medicine, v.372, no.14, pp 1324 - 1332
Pages
9
Indexed
SCI
SCIE
SCOPUS
Journal Title
New England Journal of Medicine
Volume
372
Number
14
Start Page
1324
End Page
1332
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8533
DOI
10.1056/NEJMoa1414882
ISSN
0028-4793
1533-4406
Abstract
Background: Laparoscopic resection of colorectal cancer is widely used. However, robust evidence to conclude that laparoscopic surgery and open surgery have similar outcomes in rectal cancer is lacking. A trial was designed to compare 3-year rates of cancer recurrence in the pelvic or perineal area (locoregional recurrence) and survival after laparoscopic and open resection of rectal cancer. Methods: In this international trial conducted in 30 hospitals, we randomly assigned patients with a solitary adenocarcinoma of the rectum within 15 cm of the anal verge, not invading adjacent tissues, and without distant metastases to undergo either laparoscopic or open surgery in a 2:1 ratio. The primary end point was locoregional recurrence 3 years after the index surgery. Secondary end points included disease-free and overall survival. Results: A total of 1044 patients were included (699 in the laparoscopic-surgery group and 345 in the open-surgery group). At 3 years, the locoregional recurrence rate was 5.0% in the two groups (difference, 0 percentage points; 90% confidence interval [CI], -2.6 to 2.6). Disease-free survival rates were 74.8% in the laparoscopic-surgery group and 70.8% in the open-surgery group (difference, 4.0 percentage points; 95% CI, -1.9 to 9.9). Overall survival rates were 86.7% in the laparoscopic-surgery group and 83.6% in the open-surgery group (difference, 3.1 percentage points; 95% CI, -1.6 to 7.8). Conclusions: Laparoscopic surgery in patients with rectal cancer was associated with rates of locoregional recurrence and disease-free and overall survival similar to those for open surgery. Copyright © 2015 Massachusetts Medical Society. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE