Serum sFlt-1, cystatin C and cathepsin B are potential severity markers in preeclampsia: a pilot study
- Authors
- Park, Ye Sul; Kim, Yezi; Kim, Ho Yeon; Ahn, Ki Hoon; Cho, Geum Joon; Hong, Soon-Cheol; Oh, Min Jeong; Kim, Hai Joong
- Issue Date
- Apr-2020
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Preeclampsia; sFlt-1; Cathepsin B; Cystatin C
- Citation
- Archives of Gynecology and Obstetrics, v.301, no.4, pp 955 - 962
- Pages
- 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- Archives of Gynecology and Obstetrics
- Volume
- 301
- Number
- 4
- Start Page
- 955
- End Page
- 962
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/881
- DOI
- 10.1007/s00404-020-05478-6
- ISSN
- 0932-0067
1432-0711
- Abstract
- Purpose
Preeclampsia is associated with abnormal invasion of the trophoblast through decidua and subsequently altered remodeling of the maternal spiral arteries and endothelial dysfunction. This phenomenon is explained by the dysregulation of various kinds of vascular factors and proteases. The purpose of this study was to compare the circulating levels of sFlt-1, cathepsin B, and cystatin C in preeclamptic and normotensive pregnancies.
Study design
Sixty-two pregnant women were enrolled in this prospective study. Twenty women were preeclamptic and 42 were normotensive. Serum levels of sFlt-1, cathepsin B, and cystatin C were measured using an enzyme-linked immunosorbent assay kit.
Results
Circulating levels of sFlt-1, cathepsin B, and cystatin C were significantly higher in preeclamptic than in normotensive pregnant women (p < 0.001; p = 0.017; p = 0.003). Preeclamptic women with severe features demonstrated significantly higher levels of cathepsin B (p = 0.05). Serum sFlt-1 and cystatin C levels were positively correlated with elevated systolic and diastolic blood pressure. The levels of cathepsin B were positively correlated with alanine and aspartate aminotransferase. The amount of 24 h proteinuria was positively, but non-significantly correlated with sFlt-1 and cystatin C.
Conclusions
In addition to sFlt-1 levels, the serum levels of cathepsin B and cystatin C significantly change when preeclampsia develops. These markers are associated with severity markers of elevated blood pressure and liver injury in preeclampsia.
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- Appears in
Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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