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Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread
- Authors
- Pradeep, Sunila; Kim, Seung W.; Wu, Sherry Y.; Nishimura, Masato; Chaluvally-Raghavan, Pradeep; Miyake, Takahito; Pecot, Chad V.; Kim, Sun-Jin; Choi, Hyun Jin; Bischoff, Farideh Z.; Mayer, Julie Ann; Huang, Li; Nick, Alpa M.; Hall, Carolyn S.; Rodriguez-Aguayo, Cristian; Zand, Behrouz; Dalton, Heather J.; Arumugam, Thiruvengadam; Lee, Ho Jeong; Han, Hee Dong; Cho, Min Soon; Rupaimoole, Rajesha; Mangala, Lingegowda S.; Sehgal, Vasudha; Oh, Sang Cheul; Liu, Jinsong; Lee, Ju-Seog; Coleman, Robert L.; Ram, Prahlad; Lopez-Berestein, Gabriel; Fidler, Isaiah J.; Sood, Anil K.
- Issue Date
- 14-Jul-2014
- Publisher
- CELL PRESS
- Citation
- CANCER CELL, v.26, no.1, pp 77 - 91
- Pages
- 15
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- CANCER CELL
- Volume
- 26
- Number
- 1
- Start Page
- 77
- End Page
- 91
- ISSN
- 1535-6108
1878-3686
- Abstract
- Ovarian cancer has a clear predilection for metastasis to the omentum, but the underlying mechanisms involved in ovarian cancer spread are not well understood. Here, we used a parabiosis model that demonstrates preferential hematogenous metastasis of ovarian cancer to the omentum. Our studies revealed that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsible for hematogenous omental metastasis. Elevated levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization and growth in the omentum. Depletion of ErbB3 in ovarian cancer impaired omental metastasis. Our results highlight hematogenous metastasis as an important mode of ovarian cancer metastasis. These findings have implications for designing alternative strategies aimed at preventing and treating ovarian cancer metastasis.
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Related Researcher
- Oh, Sang Cheul
- Guro Hospital (Department of Medical Oncology and Hematology, Guro Hospital)