High dose haemodialysis and haemodiafiltration parameters and the relationship with advanced vascular calcificationopen access
- Authors
- Park, Sung Keun; Kim, Won Joong; Kim, Hyun Jin; Kim, Hae Won; Kim, Beom; Lee, Hong Joo; Lee, So-Young; Lee, Yu Ho; Kim, Dong-Jin; Jeong, Kyung-Hwan; Moon, Ju-Young; Lee, Sang-Ho; Ahn, Shin Young; Ko, Gang Jee; Ryoo, Jae-Hong; Lee, Dong-Young
- Issue Date
- Mar-2020
- Publisher
- BioMed Central
- Keywords
- End-stage renal disease; Haemodialysis; Vascular calcification; Kt; V
- Citation
- BMC Nephrology, v.21, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- BMC Nephrology
- Volume
- 21
- Number
- 1
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/931
- DOI
- 10.1186/s12882-020-01738-4
- ISSN
- 1471-2369
1471-2369
- Abstract
- Background
Vascular calcification (VC) is a risk factor for cardiovascular disease in end-stage renal disease (ESRD) patients undergoing maintenance haemodialysis (MHD). However, evidence is still insufficient about the association between dialysis parameters and VC. Thus, this study was to evaluate association of dialysis parameters with VC.
Methods
We enrolled 297 ESRD patients undergoing MHD at six distinct centers in Korea. Study participants were categorized into 3 groups by the scoring system of abdominal aortic calcification based on lateral lumbar radiography (no VC group: 0, mild VC group: 1–7 and advanced VC group: 8–24). We compared the features of dialysis parameters according to the severity of VC. Multivariate logistic regression analysis was used to calculate adjusted odd ratios (ORs) and 95% confidence interval (CI) for mild and advanced VC in each haemodialysis parameter (adjusted OR [95% CI]).
Results
Pooled Kt/V (spKt/V), equilibrated Kt/V (eKt/V), standard Kt/V (stdKt/V) and the proportion of haemodiafiltration were increased along with the severity of VC. Multivariate regression analysis indicated that advanced VC was positively associated with spKt/V (5.27 [1.51–18.41]), eKt/V (6.16 [1.45–26.10]), stdKt/V (10.67 [1.74–65.52]) and haemodiafiltration (3.27 [1.74 to 6.16]).
Conclusion
High dose dialysis and haemodiafiltration were significantly associated with advanced VC.
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- Appears in
Collections - 2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles
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