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Cited 32 time in webofscience Cited 38 time in scopus
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Clinical Utility of Plasma Glypican-3 and Osteopontin as Biomarkers of Hepatocellular Carcinoma

Authors
Lee, Hyun JungYeon, Jong EunSuh, Sang JunLee, Sun JaeYoon, Eileen L.Kang, KeunheeYoo, Yang JaeKim, Ji HoonSeo, Yeon SeokYim, Hyung JoonByun, Kwan Soo
Issue Date
Mar-2014
Publisher
거트앤리버 발행위원회
Keywords
Hepatocellular carcinoma; Glypican-3; Osteopontin
Citation
Gut and Liver, v.8, no.2, pp 177 - 185
Pages
9
Indexed
SCIE
SCOPUS
KCI
Journal Title
Gut and Liver
Volume
8
Number
2
Start Page
177
End Page
185
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9543
DOI
10.5009/gnl.2014.8.2.177
ISSN
1976-2283
2005-1212
Abstract
Background/Aims α-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that are reportedly associated with tumorigenesis and metastasis. This study was conducted to evaluate the clinical utility of using plasma GPC3 and OPN as diagnostic biomarkers for HCC. Methods We measured the plasma levels of GPC3 and OPN in 120 HCC and 40 chronic liver disease (CLD) patients via an enzyme-linked immunosorbent assay. The diagnostic accuracy of each tumor marker was evaluated using receiver operating characteristic (ROC) curve analysis. Results The GPC3 levels in the HCC patients (75.8 ng/mL) were significantly higher (p=0.020) than the levels in patients with CLD (66.4 ng/mL). The area under the ROC curve (AUROC) values for GPC3 and OPN were 0.62 and 0.51, respectively. In subgroup analyses, including subgroups of HCC patients with low serum AFP and PIVKA II levels, the AUROC of GPC3 remained relatively high (0.66), and GPC3 showed a high sensitivity (62.1%) for detecting small HCC tumors. Conclusions The plasma levels of GPC3 and OPN demonstrated low diagnostic accuracy for HCC. However, GPC3 may have a complementary role in diagnosing HCC in patients with nondiagnostic levels of conventional tumor markers and with small-sized tumors.
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Byun, Kwan Soo
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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