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Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication
- Authors
- Choi, Jeong-Yoon; Park, Young-Min; Woo, Yeon Sun; Kim, Sung Un; Jung, Jin-Man; Kwon, Do-Young
- Issue Date
- 15-Feb-2014
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- JOURNAL OF THE NEUROLOGICAL SCIENCES, v.337, no.1-2, pp 243 - 244
- Pages
- 2
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE NEUROLOGICAL SCIENCES
- Volume
- 337
- Number
- 1-2
- Start Page
- 243
- End Page
- 244
- ISSN
- 0022-510X
1878-5883
- Abstract
- Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed perverted head-shaking and positional downbeat nystagmus after prescription of a high dosage of pregabalin. Since pregabalin reduces excitatory neurotransmitter secretion in the central nervous system, decreased excitatory inputs from the brainstem may lead to cerebellar dysfunction, causing perverted head-shaking and positional downbeat nystagmus. (C) 2013 Elsevier B.V. All rights reserved.
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Collections - 2. Clinical Science > Department of Neurology > 1. Journal Articles
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Related Researcher
- Kwon, Do Young
- Ansan Hospital (Department of Neurology, Ansan Hospital)