Association of ROX Index with Mechanical Ventilator Use in Sepsis Patients in the Emergency Department
- Authors
- Ahn, Sejoong; Park, Jonghak; Song, Juhyun; Kim, Jooyeong; Cho, Hanjin; Moon, Sungwoo
- Issue Date
- Jan-2022
- Publisher
- MDPI AG
- Keywords
- sepsis; emergency department; mechanical ventilator; ROX index
- Citation
- Journal of Clinical Medicine, v.11, no.2
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Clinical Medicine
- Volume
- 11
- Number
- 2
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55342
- DOI
- 10.3390/jcm11020342
- ISSN
- 2077-0383
2077-0383
- Abstract
- Detecting sepsis patients who are at a high-risk of mechanical ventilation is important in emergency departments (ED). The respiratory rate oxygenation (ROX) index is the ratio of tissue oxygen saturation/fraction of inspired oxygen to the respiratory rate. This study aimed to investigate whether the ROX index could predict mechanical ventilator use in sepsis patients in an ED. This retrospective observational study included quick sequential organ failure assessment (qSOFA) >= 2 sepsis patients that presented to the ED between September 2019 and April 2020. The ROX and ROX-heart rate (HR) indices were significantly lower in patients with mechanical ventilator use within 24 h than in those without the use of a mechanical ventilator (4.0 [3.2-5.4] vs. 10.0 [5.9-15.2], p < 0.001 and 3.9 [2.7-5.8] vs. 10.1 [5.4-16.3], p < 0.001, respectively). The area under the receiver operating characteristic (ROC) curve of the ROX and ROX-HR indices were 0.854 and 0.816 (both p < 0.001). The ROX and ROX-HR indices were independently associated with mechanical ventilator use within 24 h (adjusted hazard ratio = 0.78, 95% CI: 0.68-0.90, p < 0.001 and adjusted hazard ratio = 0.87, 95% CI 0.79-0.96, p = 0.004, respectively). The 28-day mortality was higher in the low ROX and low ROX-HR groups. The ROX and ROX-HR indices were associated with mechanical ventilator use within 24 h in qSOFA >= 2 patients in the ED.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Emergency Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.