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Cited 13 time in webofscience Cited 14 time in scopus
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Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior

Authors
Jeong, BoraKim, Kwang-KonLee, Tae-HwanKim, Han-RaePark, Byong-SeoPark, Jeong-WooJeong, Jin-KwonSeong, Jae-YoungLee, Byung-Ju
Issue Date
Feb-2022
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
energy homeostasis; appetite regulation; hypothalamus; spexin
Citation
Biomolecules, v.12, no.2
Indexed
SCIE
SCOPUS
Journal Title
Biomolecules
Volume
12
Number
2
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55482
DOI
10.3390/biom12020236
ISSN
2218-273X
2218-273X
Abstract
Spexin (SPX) is a recently identified neuropeptide that is believed to play an important role in the regulation of energy homeostasis. Here, we describe a mediating function of SPX in hypothalamic leptin action. Intracerebroventricular (icv) SPX administration induced a decrease in food intake and body weight gain. SPX was found to be expressed in cells expressing leptin receptor ObRb in the mouse hypothalamus. In line with this finding, icv leptin injection increased SPX mRNA in the ObRb-positive cells of the hypothalamus, which was blocked by treatment with a STAT3 inhibitor. Leptin also increased STAT3 binding to the SPX promoter, as measured by chromatin immunoprecipitation assays. In vivo blockade of hypothalamic SPX biosynthesis with an antisense oligodeoxynucleotide (AS ODN) resulted in a diminished leptin effect on food intake and body weight. AS ODN reversed leptin's effect on the proopiomelanocortin (POMC) mRNA expression and, moreover, decreased leptin-induced STAT3 binding to the POMC promoter sequence. These results suggest that SPX is involved in leptin's action on POMC gene expression in the hypothalamus and impacts the anorexigenic effects of leptin.
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