Clinical Features and Long-term Prognosis of Crohn's Disease in Korea: Results from the Prospective CONNECT Study
- Hong, Seung Wook; Ye, Byong Duk; Cheon, Jae Hee; Lee, Ji Hyun; Koo, Ja Seol; Jang, Byung Ik; Lee, Kang-Moon; Kim, You Sun; Kim, Tae Oh; Im, Jong Pil; Song, Geun Am; Jung, Sung-Ae; Kim, Hyun Soo; Park, Dong Il; Kim, Hyun-Soo; Huh, Kyu Chan; Kim, Young-Ho; Cha, Jae Myung; Seo, Geom Seog; Choi, Chang Hwan; Song, Hyun Joo; Baik, Gwang Ho; Kim, Ji Won; Shin, Sung Jae; Park, Young Sook; Lee, Chang Kyun; Lee, Jun; Jung, Sung Hee; Jung, Yunho; Park, Sung Chul; Joo, Young-Eun; Jeen, Yoon Tae; Han, Dong Soo; Yang, Suk-Kyun; Kim, Hyo Jong; Kim, Won Ho; Kim, Joo Sung
- Issue Date
- 거트앤리버 발행위원회
- Cohort studies; Crohn disease; Prognosis; Multicenter study; Korea
- Gut and Liver, v.16, no.6, pp.907 - 920
- Journal Title
- Gut and Liver
- Start Page
- End Page
- Background/Aims: The prospective Crohn’s Disease Clinical Network and Cohort study is a nationwide multicenter cohort study of patients with Crohn’s disease (CD) in Korea, aiming to prospectively investigate the clinical features and long-term prognosis associated with CD.
Methods: Patients diagnosed with CD between January 2009 and September 2019 were prospectively enrolled. They were divided into two cohorts according to the year of
diagnosis: cohort 1 (diagnosed between 2009 and 2011) versus cohort 2 (between 2012 and 2019).
Results: A total of 1,175 patients were included, and the median follow-up duration was 68 months (interquartile range, 39.0 to 91.0 months). The treatment-free durations for thiopurines (p<0.001) and anti-tumor necrosis factor agents (p=0.018) of cohort 2 were shorter than those of cohort 1. Among 887 patients with B1 behavior at diagnosis, 149 patients (16.8%) progressed to either B2 or B3 behavior during follow-up. Early use of thiopurine was associated with a reduced risk of behavioral progression (adjusted hazard ratio [aHR], 0.69; 95% confidence interval [CI], 0.50 to 0.90), and family history of inflammatory bowel disease was associated with an increased risk of behavioral progression (aHR, 2.29; 95% CI, 1.16 to 4.50). One hundred forty-one patients (12.0%) underwent intestinal resection, and the intestinal resection-free survival time was significantly longer in cohort 2 than in cohort 1 (p=0.003). The early use of thiopurines (aHR, 0.35; 95% CI, 0.23 to 0.51) was independently associated with a reduced risk of intestinal resection.
Conclusions: The prognosis of CD in Korea appears to have improved over time, as evidenced by the decreasing intestinal resection rate. Early use of thiopurines was associated with an improved prognosis represented by a reduced risk of intestinal resection.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.