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Anti-Viral Activities of Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Against Human Respiratory Virusesopen access

Authors
Oh, Soo-JinLee, Eun-NaPark, Joo-HooLee, Jae KyungCho, Geum JoonPark, Il-HoShin, Ok Sarah
Issue Date
Apr-2022
Publisher
Frontiers Media S.A.
Keywords
small extracellular vesicles (exosomes); UCMSCs; respiratory viruses; anti-viral; ALI (Air-Liquid Interface)
Citation
Frontiers in cellular and infection microbiology, v.12
Indexed
SCIE
SCOPUS
Journal Title
Frontiers in cellular and infection microbiology
Volume
12
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/60968
DOI
10.3389/fcimb.2022.850744
Abstract
The endemic and pandemic caused by respiratory virus infection are a major cause of mortality and morbidity globally. Thus, broadly effective antiviral drugs are needed to treat respiratory viral diseases. Small extracellular vesicles derived from human umbilical cord mesenchymal stem cells (U-exo) have recently gained attention as a cell-free therapeutic strategy due to their potential for safety and efficacy. Anti-viral activities of U-exo to countermeasure respiratory virus-associated diseases are currently unknown. Here, we tested the antiviral activities of U-exo following influenza A/B virus (IFV) and human seasonal coronavirus (HCoV) infections in vitro. Cells were subject to IFV or HCoV infection followed by U-exo treatment. U-exo treatment significantly reduced IFV or HCoV replication and combined treatment with recombinant human interferon-alpha protein (IFN-alpha) exerted synergistically enhanced antiviral effects against IFV or HCoV. Interestingly, microRNA (miR)-125b, which is one of the most abundantly expressed small RNAs in U-exo, was found to suppress IFV replication possibly via the induction of IFN-stimulated genes (ISGs). Furthermore, U-exo markedly enhanced RNA virus-triggered IFN signaling and ISGs production. Similarly, human nasal epithelial cells cultured at the air-liquid interface (ALI) studies broadly effective anti-viral and anti-inflammatory activities of U-exo against IFV and HCoV, suggesting the potential role of U-exo as a promising intervention for respiratory virus-associated diseases.
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3. Graduate School > Biomedical Research Center > 1. Journal Articles
2. Clinical Science > Department of Otorhinolaryngology-Head and Neck Surgery > 1. Journal Articles
2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
4. Research institute > Institute for Medical Device Clinical Trial > 1. Journal Articles

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Park, Il-Ho
Guro Hospital (Department of Otorhinolaryngology-Head and Neck Surgery, Guro Hospital)
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