Association between interleukin-1, interleukin-6, and tumor necrosis factor-alpha polymorphisms and juvenile idiopathic arthritis: a meta-analysis

Abstract

INTRODUCTION: In juvenile idiopathic arthritis (JIA), interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-alpha) are associated with development and progression of JIA. We investigated whether IL-1, IL-6, and TNF-alpha polymorphisms were associated with susceptibility to JIA.

EVIDENCE ACQUISITION: A meta-analysis was conducted on the associations between IL-1 alpha-899 C/T, IL-1 beta-511 C/T, IL-6-174 G/C, and TNF-alpha-308 G/A and -238 G/A polymorphisms, and JIA (PubMed and Embase).

EVIDENCE SYNTHESIS: A total of 27 studies involving 4678 JIA patients and 7634 controls were considered in the meta-analysis. There was no association between the IL-1 alpha-899 C/T, IL-1 beta-511 C/T, IL-6-174 G/C, and TNF-alpha-308 G/A and -238 G/A polymorphisms, and JIA in allele contrast or any other genetic models. In subgroup analysis based on subtype, except for the dominant model of TNF-alpha-238 G/A, systemic JIA was not significantly associated with IL-6 and TNF-alpha polymorphisms. In Caucasians, the dominant and additive models of IL-1 beta-511 C/T were significantly associated with JIA (odds ratio [OR] 1.48, 95% confidence interval [CI] 1.09-2.00, P=0.01; OR 1.46, 95% CI 1.05-2.03, P=0.02, respectively).

CONCLUSIONS: This meta-analysis showed no association between IL-1, IL-6, and TNF-alpha polymorphisms, and JIA, but the TT genotype of IL-1 beta-511 C/T was associated with higher prevalence of JIA in Caucasians.