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Cited 3 time in webofscience Cited 2 time in scopus
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Submolecular Ligand Size and Spacing for Cell Adhesion

Authors
Kim, YuriKoo, Thomas MyeongseokThangam, RamarKim, Myeong SooJang, Woo YoungKang, NayeonMin, SunhongKim, Seong YeolYang, LetaoHong, HyunsikJung, Hee JoonKoh, Eui KwanPatel, Kapil D.Lee, SungkyuFu, Hong EnJeon, Yoo SangPark, Bum ChulKim, Soo YoungPark, SteveLee, JunminGu, LuoKim, Dong-HyunKim, Tae-HyungLee, Ki-BumJeong, Woong KyoPaulmurugan, RamasamyKim, Young KeunKang, Heemin
Issue Date
Jul-2022
Publisher
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords
cell adhesion; ligand size; ligand spacing; macrophage modulation; nanoassemblies; submolecular ligands
Citation
Advanced Materials, v.34, no.27
Indexed
SCIE
SCOPUS
Journal Title
Advanced Materials
Volume
34
Number
27
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61072
DOI
10.1002/adma.202110340
ISSN
0935-9648
Abstract
Cell adhesion occurs when integrin recognizes and binds to Arg-Gly-Asp (RGD) ligands present in fibronectin. In this work, submolecular ligand size and spacing are tuned via template-mediated in situ growth of nanoparticles for dynamic macrophage modulation. To tune liganded gold nanoparticle (GNP) size and spacing from 3 to 20 nm, in situ localized assemblies of GNP arrays on nanomagnetite templates are engineered. 3 nm-spaced ligands stimulate the binding of integrin, which mediates macrophage-adhesion-assisted pro-regenerative polarization as compared to 20 nm-spaced ligands, which can be dynamically anchored to the substrate for stabilizing integrin binding and facilitating dynamic macrophage adhesion. Increasing the ligand size from 7 to 20 nm only slightly promotes macrophage adhesion, not observed with 13 nm-sized ligands. Increasing the ligand spacing from 3 to 17 nm significantly hinders macrophage adhesion that induces inflammatory polarization. Submolecular tuning of ligand spacing can dominantly modulate host macrophages.
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Jeong, Woong Kyo
Anam Hospital (Department of Orthopedic Surgery, Anam Hospital)
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