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Cited 1 time in webofscience Cited 1 time in scopus
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Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes

Authors
Lee, Sung HwanYim, Sun YoungJeong, Yun SeongLi, Qi‐XiangKang, Sang‐HeeSohn, Bo HwaKumar, Shwetha V.Shin, Ji‐HyunChoi, You RheeShim, Jae‐JunKim, HayeonKim, Ji HoonKim, ShinGuo, ShengJohnson, Randy L.Kaseb, AhmedKang, Koo JeongChun, Yun ShinJang, Hee JinLee, Byoung GillWoo, Hyun GooHa, Min JinAkbani, RehanRoberts, Lewis R.Wheeler, David A.Lee, Ju‐Seog
Issue Date
Dec-2022
Publisher
John Wiley & Sons Inc.
Citation
Hepatology, v.76, no.6, pp.1634 - 1648
Indexed
SCIE
SCOPUS
Journal Title
Hepatology
Volume
76
Number
6
Start Page
1634
End Page
1648
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61091
DOI
10.1002/hep.32490
ISSN
0270-9139
Abstract
Background and Aims Although many studies revealed transcriptomic subtypes of HCC, concordance of the subtypes are not fully examined. We aim to examine a consensus of transcriptomic subtypes and correlate them with clinical outcomes. Approach and Results By integrating 16 previously established genomic signatures for HCC subtypes, we identified five clinically and molecularly distinct consensus subtypes. STM (STeM) is characterized by high stem cell features, vascular invasion, and poor prognosis. CIN (Chromosomal INstability) has moderate stem cell features, but high genomic instability and low immune activity. IMH (IMmune High) is characterized by high immune activity. BCM (Beta-Catenin with high Male predominance) is characterized by prominent β-catenin activation, low miRNA expression, hypomethylation, and high sensitivity to sorafenib. DLP (Differentiated and Low Proliferation) is differentiated with high hepatocyte nuclear factor 4A activity. We also developed and validated a robust predictor of consensus subtype with 100 genes and demonstrated that five subtypes were well conserved in patient-derived xenograft models and cell lines. By analyzing serum proteomic data from the same patients, we further identified potential serum biomarkers that can stratify patients into subtypes. Conclusions Five HCC subtypes are correlated with genomic phenotypes and clinical outcomes and highly conserved in preclinical models, providing a framework for selecting the most appropriate models for preclinical studies.
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2. Clinical Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Yim, Sun Young
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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