Accelerated functional brain aging in pre-clinical familial Alzheimer's diseaseopen access
- Authors
- Gonneaud, Julie; Baria, Alex T.; Binette, Alexa Pichet; Gordon, Brian A.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Jucker, Mathias; Levin, Johannes; Salloway, Stephen; Farlow, Martin; Gauthier, Serge; Benzinger, Tammie L. S.; Morris, John C.; Bateman, Randall J.; Breitner, John C. S.; Poirier, Judes; Vachon-Presseau, Etienne; Villeneuve, Sylvia; Alzheimer’s Disease Neuroimaging Initiative; Dominantly Inherited Alzheimer Network Study Group; Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease Research Grou; Roh, Jee Hoon (DIAN)
- Issue Date
- Sep-2021
- Publisher
- Nature Publishing Group
- Citation
- Nature Communications, v.12, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- Nature Communications
- Volume
- 12
- Number
- 1
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61092
- DOI
- 10.1038/s41467-021-25492-9
- ISSN
- 2041-1723
- Abstract
- Alzheimer's disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer's disease. Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (A beta) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18-94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant A beta pathology.
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- Appears in
Collections - 1. Basic Science > Department of Physiology > 1. Journal Articles
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