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Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseasesopen access

Authors
Lee, Han AhChang, YoungSung, Pil SooYoon, Eileen L.Lee, Hye WonYoo, Jeong-JuLee, Young-SunAn, JihyunSong, Do SeonCho, Young YounKim, Seung UpKim, Yoon Jun
Issue Date
Jul-2022
Publisher
대한간학회
Keywords
Nonalcoholic fatty liver disease; Viral hepatitis; Cirrhosis; Non-antidiabetic drugs; Treatment
Citation
Clinical and Molecular Hepatology, v.28, no.3, pp.425 - 472
Indexed
SCIE
SCOPUS
KCI
Journal Title
Clinical and Molecular Hepatology
Volume
28
Number
3
Start Page
425
End Page
472
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61343
DOI
10.3350/cmh.2022.0186
ISSN
2287-2728
Abstract
The global burden of chronic liver disease (CLD) is substantial. Due to the limited indication of and accessibility to antiviral therapy in viral hepatitis and lack of effective pharmacological treatment in nonalcoholic fatty liver disease, the beneficial effects of antidiabetics and non–antidiabetics in clinical practice have been continuously investigated in patients with CLD. In this narrative review, we focused on non-antidiabetic drugs, including ursodeoxycholic acid, silymarin, dimethyl4,4’-dimethoxy-5,6,5’,6’-dimethylenedixoybiphenyl-2,2’-dicarboxylate, L-ornithine L-aspartate, branched chain amino acids, statin, probiotics, vitamin E, and aspirin, and summarized their beneficial effects in CLD. Based on the antioxidant, anti-inflammatory properties, and regulatory functions in glucose or lipid metabolism, several non–antidiabetic drugs have shown beneficial effects in improving liver histology, aminotransferase level, and metabolic parameters and reducing risks of hepatocellular carcinoma and mortality, without significant safety concerns, in patients with CLD. Although the effect as the centerpiece management in patients with CLD is not robust, the use of these non-antidiabetic drugs might be potentially beneficial as an adjuvant or combined treatment strategy.
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Lee, Young Sun
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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