Preliminary Study for Quantitative Assessment of Sacroiliitis Activity Using Bone SPECT/CT: Comparison of Diagnostic Performance of Quantitative Parameters
- Authors
- Lee, Koeun; Kim, Hyunji; Kim, Yong-il; Park, Bumwoo; Shim, Woo Hyun; Oh, Jungsu S.; Hong, Seokchan; Kim, Yong-Gil; Ryu, Jin-Sook
- Issue Date
- Dec-2022
- Publisher
- 대한핵의학회
- Keywords
- Sacroiliitis; Sacroiliac joint; Bone scintigraphy; SPECT/CT; SUV; Quantitative analysis
- Citation
- Nuclear Medicine and Molecular Imaging, v.56, no.6, pp 282 - 290
- Pages
- 9
- Indexed
- SCOPUS
ESCI
KCI
- Journal Title
- Nuclear Medicine and Molecular Imaging
- Volume
- 56
- Number
- 6
- Start Page
- 282
- End Page
- 290
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61417
- DOI
- 10.1007/s13139-022-00766-2
- ISSN
- 1869-3474
1869-3482
- Abstract
- Purpose
We compared the feasibility of quantitative analysis methods using bone SPECT/CT with those using planar bone scans to assess active sacroiliitis.
Methods
We retrospectively reviewed whole-body bone scans and pelvic bone SPECT/CTs of 8 patients who had clinically confirmed sacroiliitis and enrolled 24 patients without sacroiliitis as references. The volume of interest of each sacroiliac joint, including both the ilium and sacrum, was drawn. Active arthritis zone (AAZ) was defined as the zone of voxels with higher SUV than sacral mean SUV within the VOI of SI joint. Then, the following SPECT/CT quantitative parameters, SUVmax (maximum SUV), SUV50% (mean SUV in highest 50% of SUV), and SUV-AAZ, and the ratio of those values to sacral mean SUV (SUVmax/S, SUV50%/S, SUV-AAZ/S) were calculated. For the planar bone scan, the mean count ratio of SI joint/sacrum (SI/S) was conventionally measured.
Results
Most of the SPECT/CT parameters of the sacroiliitis group were significantly higher than the normal group, whereas SI/S of the planar bone scan was not significantly different between the two groups. In receiver operating characteristic curve analysis, SUV-AAZ/S showed the highest AUC of 0.992, followed by SUV50%/S and SUVmax/S. All ratio parameters of the SPECT/CT showed higher AUC values than the SUV parameters of SI joint or SI/S of the planar scan.
Conclusions
The quantitative analyses of bone SPECT/CT showed better performance in assessing active sacroiliitis than the planar bone scan. SPECT/CT parameters using the ratio of the SI joint to sacrum showed more favorable results than SUV parameters such as SUVmax, SUV50%, and SUV-AAZ.
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Collections - 2. Clinical Science > Department of Nuclear Medicine > 1. Journal Articles
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