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FDG metabolic parameter-based models for predicting recurrence after upfront surgery in synchronous colorectal cancer liver metastasis

Authors
Lee, Hyo SangKwon, Hyun WooLim, Seok-ByungKim, Jin CheonYu, Chang SikHong, Yong SangKim, Tae WonOh, MinyoungHan, SangwonOh, Jae HwanPark, SohyunKim, Tae-SungKim, Seok-kiKim, Hyun JooKwak, Jae YoungOh, Ho-SukKim, SungeunKwak, Jung-MyunLee, Ji SungKim, Jae Seung
Issue Date
Sep-2022
Publisher
Springer Verlag
Keywords
Fluorodeoxyglucose F18; Positron emission tomography; Colorectal neoplasms; Liver neoplasms; Prognosis
Citation
European Radiology
Indexed
SCIE
SCOPUS
Journal Title
European Radiology
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61546
DOI
10.1007/s00330-022-09141-3
ISSN
0938-7994
Abstract
Objective This study aimed to develop and validate post- and preoperative models for predicting recurrence after curative-intent surgery using an FDG PET-CT metabolic parameter to improve the prognosis of patients with synchronous colorectal cancer liver metastasis (SCLM). Methods In this retrospective multicenter study, consecutive patients with resectable SCLM underwent upfront surgery between 2006 and 2015 (development cohort) and between 2006 and 2017 (validation cohort). In the development cohort, we developed and internally validated the post- and preoperative models using multivariable Cox regression with an FDG metabolic parameter (metastasis-to-primary-tumor uptake ratio [M/P ratio]) and clinicopathological variables as predictors. In the validation cohort, the models were externally validated for discrimination, calibration, and clinical usefulness. Model performance was compared with that of Fong’s clinical risk score (FCRS). Results A total of 374 patients (59.1 ± 10.5 years, 254 men) belonged in the development cohort and 151 (60.3 ± 12.0 years, 94 men) in the validation cohort. The M/P ratio and nine clinicopathological predictors were included in the models. Both postoperative and preoperative models showed significantly higher discrimination than FCRS (p < .05) in the external validation (time-dependent AUC = 0.76 [95% CI 0.68–0.84] and 0.76 [0.68–0.84] vs. 0.65 [0.57–0.74], respectively). Calibration plots and decision curve analysis demonstrated that both models were well calibrated and clinically useful. The developed models are presented as a web-based calculator (https://cpmodel.shinyapps.io/SCLM/) and nomograms. Conclusions FDG metabolic parameter-based prognostic models are well-calibrated recurrence prediction models with good discriminative power. They can be used for accurate risk stratification in patients with SCLM.
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2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
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Kwon, Hyun Woo
Anam Hospital (Department of Nuclear Medicine, Anam Hospital)
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