What are the risk factors for recurrent UTI with repeated ESBL-producing Enterobacteriaceae? A retrospective cohort study
- Authors
- Ahn, Sun Tae; Lee, Hyun Soo; Han, Da Eun; Lee, Dong Hyun; Kim, Jong Wook; Park, Min Gu; Park, Hong Seok; Moon, Du Geon; Oh, Mi Mi
- Issue Date
- Jan-2023
- Publisher
- Elsevier Limited
- Keywords
- Urinary tract infection; Enterobacteriaceae; Recurrent UTI
- Citation
- Journal of Infection and Chemotherapy, v.29, no.1, pp 72 - 77
- Pages
- 6
- Indexed
- SCOPUS
- Journal Title
- Journal of Infection and Chemotherapy
- Volume
- 29
- Number
- 1
- Start Page
- 72
- End Page
- 77
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62100
- DOI
- 10.1016/j.jiac.2022.09.020
- ISSN
- 1341-321X
1437-7780
- Abstract
- Introduction
A previous study has shown that two-thirds of patients with urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae experience recurrence with the same bacteria on subsequent UTI episodes. However, little is known about which patients suffer from UTI due to ESBL-producing Enterobacteriaceae repeatedly. This study aimed to investigate the risk factors for recurrent UTI due to repeated ESBL-producing organism infections.
Methods
This retrospective, single-center, observational cohort study screened all patients with UTI caused by ESBL-producing strains between January 2012 and April 2019. Among the patients who were followed up, patients who experienced UTI recurrence were enrolled and divided into two groups: ESBL recurrence group and non-ESBL recurrence group. Multivariable Cox proportional hazards regression analyses were performed to evaluate the association between patient characteristics and the development of recurrent UTI caused by ESBL-producing Enterobacteriaceae.
Results
A total of 330 patients were followed up after the diagnosis of UTI caused by ESBL-producing organisms. Among the patients, 115 (34.8%) experienced UTI recurrence, and 71 (61.7%) of them experienced subsequent recurrent UTI due to ESBL-producing organisms. Patient's age (hazard ratio [HR], 1.02; 95% confidence interval [CI], 1.00–1.04; P = 0.046) and recurrent UTI history (HR, 1.69; 95% CI, 1.05–2.72; P = 0.031) were significantly associated with an increased risk of recurrence with ESBL-producing Enterobacteriaceae.
Conclusion
These findings showed that a history of previous frequent UTI recurrence is the risk factor for recurrence of UTI due to repeated ESBL producing Enterobacteriaceae infections.
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Collections - 2. Clinical Science > Department of Urology > 1. Journal Articles
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