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Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs)
- Authors
- Park, Eui Ho; Han, Hee Chul
- Issue Date
- Nov-2021
- Publisher
- Academic Press
- Subjects
- Pain; Nociceptor; Glutamate; Peripheral nervous system; Dorsal root ganglion; Trigeminal ganglion; Peripheral group III metabotropic glutamate receptors; Negative modulation; Activity-dependent inhibition; Glial cells
- Abstract
- Pain perception serves to protect living organism against an actual or potential tissue damage. Glutamatergic signaling of nervous system plays a crucial role in initiating and maintaining pain. It is important to note that the glutamatergic signaling in peripheral nervous system (PNS) is responsible for the first phase of pain processing. Recent animal studies support that some types of glutamate receptors such as NMDA receptor and group I metabotropic glutamate receptors (mGluRs) in cell bodies and primary afferent fibers of PNS can potentiate the nociceptive processing. However, much interest was less present in the role of peripheral group III mGluRs for regulating pain. Therefore, the present review will focus on peripheral group III mGluRs of PNS that can offer a better understanding of inhibitory role and therapeutic potential in pain processing.
- Table Of Contents
- I. Molecular and cellular aspects 1. Gene expression, KCNQ/Kv7 channels and neuropathic pain (Q. Yang and Zizhen Wu) 2. The NTRK1 gene and congenital insensitivity to pain (Maryam Sobhani) 3. Prdm12, a key transcriptional regulator of the nociceptive lineage (Eric Joseph Bellefroid) 4. Linking the genetics of fibromyalgia and painFernando (Estevez-Lopez) 5. Fentanyl: Polymorphisms, and adverse events (Ana M. Peiro) 6. Propofol anesthesia and molecular changes in the brain (Vesna Pesic) 7. Protein Kinase G is a Molecular Switch for Pain (Y-J Sung) 8. Adrenergic agonists and the mu opioid receptor (Robert Root-Bernstein) 9. Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic systemL (Hipolito, Yolanda Campos-Jurado, Javier Cuitavi Javier, Natalia Landsberg and Jesús David Lorente) 10. Clinacanthus nutans, analgesia and the l-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathway (Zainul Amiruddin Zakaria) 11. alpha2/3-selective GABAA receptor PAMs as pain medications (Jeffrey Witkin and Rok Cerne) 12. alpha5GABAA receptors and their role in pain perception (Rodolfo Delgado-Lezama, Úrzula Franco-Enzástiga, Yarim De la Luz-Cuellar, Luis Eduardo Hernández-Reyes, Guadalupe Raya-Tafolla, Janet Murbartián, Vinicio Granados-Soto and Jorge Elías Torres-López) 13. ATP sensitive potassium channels in pain and analgesia (Celina MC Lotufo, Tais Campos Lima and Débora Oliveira Santos) 14. Astrocyte-neuron lactate shuttle and pain (Masahiro Ohsawa and Keisuke Miyamoto) 15. Nociception and sweet solutions: applications to inflammatory pain (KHawla Nuseir) 16. Interlinking Interleukin-33 (IL-33), neuroinflammation and neuropathic pain (Camila Ferraz, Fernanda Soares Rasquel-Oliveira, Sergio Marques Borghi, Anelise Franciosi, Thacyana Carvalho, Telma Saraiva-Santos, Nayara Anitelli Artero, Rubia Casagrande and Waldiceu A. Verri Jr.) 17. Neurons of the parabrachial nucleus, nociceptive input and pain pathways (Masashi Fujitani) 18. Anterior cingulate cortex, pain perception and pathological neuronal plasticity during chronic pain (Fernando Kasanetz) 19. Sleep deprivation headaches and Fos immunohistochemistry (JeongWook Park and Seonghoon Kim) 20. Antinociceptive glucagon-like peptides (Duygun Altıntaş Aykan) 21. Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs) (Hee Chul Han and Eui Ho Park) 22. TRPM -8 receptor and menthol in pain management (Merja Kokki) II. Physiology, imaging and physical recordings 23. Anesthetic and proconvulsant effects of ketamine on EEG (Shaila Gowda and Charles Akos Szabo) 24. Electroencephalography and anesthetic doses of ketamine (Jamie Sleigh) 25. Linking heart function and analgesia (Giustino Varrassi, Giorgia Saltelli, Antonella Paladini and Martina Rekatsina) 26. Computed Tomography-guided procedures for epidural injections (Semih Gungor) 27. Chronic pain: Linking deep brain stimulation and sensory functional MRI (Witold Henryk Polanski and Johann Klein) 28. Neurocognition and placebo analgesia: linking in functional magnetic resonance imaging (Sara Palermo) 29. Linking the cortex, functional spectroscopy and pain: features and applications (Wolnei Caumo Sr.) 30. Muscle origins of myofascial pain syndrome (Eva María Martinez-Jiménez) III. Psychology and Behaviour 31. Behavioral markers of pain (Scott Holmes, Aisling E. Quinlan and Meghan Pierce) 32. Adverse life events, sensitization of spinal nociception, and chronic pain risk (Jamie Lynn Rhudy and Natalie Hellman) 33. Cognitive-affective modulation of pain: The Placebo and nocebo phenomena and their impact on pain treatment (Sergiu Albu, Hans Linsenbardt and Mary Meagher) 34. Nociception-related behavioral phenotypes in adult zebrafish (Fabiano Vargas Costa Sr.) 35. Pain, implantable pain devices and psychosocial aspects as a narrative (K. Chakravarthy and Vishal Varshney) 36. Influence of psychological factors in myofascial pain (César Calvo-Lobo Sr.) IV. Resources 37. Resources (Rajkumar Rajendram)
- Pages
- 458
- Start Page
- 227
- End Page
- 238
- ISBN
- 9780128205891
- Files in This Item
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Related Researcher
- Han, Hee Chul
- College of Medicine (Department of Physiology)