Efficacy and Safety of Maca (Lepidium meyenii) in Patients with Symptoms of Late-Onset Hypogonadism: A Randomized, Double-Blind, Placebo-Controlled Clinical Trialopen access
- Authors
- Shin, Dongho; Jeon, Seung Hwan; Piao, Junjie; Park, Hyo Jung; Tian, Wen Jie; Moon, Du Geon; Ahn, Sun Tae; Jeon, Kyung-Hwa; Zhu, Guan Qun; Park, Ilbum; Park, Hyun-Je; Bae, Woong Jin; Cho, Hyuk Jin; Hong, Sung-Hoo; Kim, Sae Woong
- Issue Date
- Jul-2023
- Publisher
- 대한남성과학회
- Keywords
- Herbal medicine; Hypogonadism; Lepidium; Physiological; Sexual dysfunction
- Citation
- The World Journal of Men's Health, v.41, no.3, pp 692 - 700
- Pages
- 9
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- The World Journal of Men's Health
- Volume
- 41
- Number
- 3
- Start Page
- 692
- End Page
- 700
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62308
- DOI
- 10.5534/wjmh.220112
- ISSN
- 2287-4208
2287-4690
- Abstract
- Purpose
To evaluated the efficacy and safety of gelatinized Maca (Lepidium meyenii) for eugonadal patients with late onset hypogonadism symptoms (LOH).
Materials and Methods
Participants were instructed to receive 1,000 mg of Maca or placebo, two pills at a time, three times per day for 12 weeks before food intake. To evaluate the efficacy of the drug, Aging Males' Symptoms scale (AMS), Andro -gen Deficiency in the Aging Males (ADAM), International Prostate Symptom Score (IPSS), and International Index of Erectile Function (IIEF) questionnaires, serologic tests (total testosterone and free testosterone, total cholesterol, high density lipopro-tein cholesterol, low density lipoprotein cholesterol, triglyceride), body weight, and waist circumference were assessed at 4 and 12 weeks after treatment.
Results
A total of 80 participants were enrolled and randomly assigned to Maca treated group (n=41) or the placebo group (n=39). AMS, IIEF, and IPSS were significantly (p<0.05) improved in Maca treated group than in the placebo group. ADAM positive rate was also significantly (p<0.0001) decreased in Maca treated group.
Conclusions
Maca may be considered an effective and safe treatment for eugonadal patients with late onset hypogonadism symptoms.
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Collections - 2. Clinical Science > Department of Urology > 1. Journal Articles
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