Quisqualis indica extract for men with lower urinary tract symptoms: A randomized, double-blind, placebo-controlled trialopen access
- Authors
- Shin, Dongho; Zhu, Guan Qun; Tian, Wen Jie; Ahn, Sun Tae; Jeon, Seung Hwan; Cho, Hyuk Jin; Ha, U-Syn; Hong, Sung-Hoo; Lee, Ji Youl; Kim, Sae Woong; Moon, Du Geon; Bae, Woong Jin
- Issue Date
- Jan-2023
- Publisher
- 대한비뇨기과학회
- Keywords
- Dihydrotestosterone; Pharmacologic effects; Plant extract; Safety
- Citation
- Investigative and Clinical Urology, v.64, no.1, pp 20 - 30
- Pages
- 11
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Investigative and Clinical Urology
- Volume
- 64
- Number
- 1
- Start Page
- 20
- End Page
- 30
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62339
- DOI
- 10.4111/icu.20220290
- ISSN
- 2466-0493
2466-054X
- Abstract
- Purpose
To evaluate the efficacy and safety of Quisqualis indica in men with moderate lower urinary tract symptoms (LUTS).
Materials and Methods
A total of 135 subjects with International Prostate Symptom Score (IPSS) of 8–19 were randomized in 2 centers from June 2018 to April 2019. Patients were assigned into one of the three groups: a low-dose group (LG, 1,000 mg Q. indica), a high-dose group (HG, 2,000 mg Q. indica) or a placebo group (PG). The primary endpoint was the change of IPSS at the end of treatment from baseline. Secondary end points included the changes of prostate specific antigen, testosterone, dihydrotestosterone, maximum urinary flow rate (Qmax), postvoid residual volume (PVR) and International Index of Erectile Function-5 (IIEF-5), with drug safety.
Results
113 patients were able to finish the study. Compared to the PG, total IPSS in the LG and the HG was significantly improved at 6 weeks and 12 weeks. For IPSS subscores, LG showed improvements in all except for urgency and quality of life at 6 weeks. HG showed improvements in incomplete emptying and frequency at 6 weeks and 12 weeks along with improvements in intermittency, straining, and quality of life at 12 weeks. For IIEF-5 subscores, orgasmic function and overall satisfaction improved in HG when compared to PG at 12 weeks. Lastly, increase of Qmax and decrease of PVR was observed at 6 weeks in LG.
Conclusions
12-week treatment with Q. indica has a therapeutic effect and is well tolerated in patients with LUTS.
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- Appears in
Collections - 2. Clinical Science > Department of Urology > 1. Journal Articles
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