Six-month longitudinal immune kinetics after mRNA-1273 vaccination: Correlation of peak antibody response with long-term, cross-reactive immunityopen access
- Authors
- Choi, Min Joo; Heo, Jung Yeon; Seo, Yu Bin; Yoon, Young Kyung; Sohn, Jang Wook; Noh, Ji Yun; Cheong, Hee Jin; Kim, Woo Joo; Choi, Ju-yeon; Kim, Hwa Jung; Lee, Young Jae; Lee, Hye Won; Kim, Sung Soon; Kim, Byoungguk; Song, Joon Young
- Issue Date
- Jan-2023
- Publisher
- Frontiers Media S.A.
- Keywords
- SARS-CoV-2 infection; mRNA-1273 vaccine; COVID-19; cellular immunity; humoral immunity
- Citation
- Frontiers in Immunology, v.13
- Indexed
- SCIE
SCOPUS
- Journal Title
- Frontiers in Immunology
- Volume
- 13
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62357
- DOI
- 10.3389/fimmu.2022.1035441
- ISSN
- 1664-3224
1664-3224
- Abstract
- Background
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and the persistence of the pandemic, even with mass coronavirus disease 2019 (COVID-19) vaccination, have raised questions about the durability of immunity and extent of cross-reactive immunity after vaccination. This study aimed to characterize the humoral and cellular immune response to the mRNA-1273 vaccine using a prospective longitudinal cohort.
Methods
We recruited 177 young SARS-CoV-2 infection-naive adults. Two doses of mRNA-1273 vaccine were administered at 28-day intervals, and blood samples were collected at five time points: pre-vaccination (T0), 4 weeks after the first (T1) and second dose (T2), and 3 months (T3) and 6 months (T4) after the first dose. Anti-SARS-CoV-2 spike protein (anti-S) IgG antibody, neutralizing antibody, and T-cell immune responses were evaluated.
Results
The two-dose mRNA-1273 vaccination induced robust anti-SARS-CoV-2 antibody responses, which remained higher than the titers at T1 until T4. A higher peak anti-S antibody titer at T2 was associated with better cross-reactive immunity against Delta and Omicron variants and long-lasting (anti-S IgG and neutralizing antibody) humoral immunity up to T4. The overall T-cell immune response was not correlated with peak antibody titers (T-lymphocyte subpopulation analysis was not performed).
Conclusion
This study showed that an early strong antibody response is predictive of longer humoral immunity and better cross-reactive neutralizing immunity against Delta and Omicron variants.
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- Appears in
Collections - 2. Clinical Science > Department of Infectious Diseases > 1. Journal Articles
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