Relationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Studyopen access
- Authors
- Jin, Sejong; Choi, Eun-Ji; Choi, Yoon Ji; Min, Won Kee; Park, Ju Yeon; Yoon, Seung Zhoo
- Issue Date
- Jan-2023
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- ALOX5AP; peripheral artery disease; single nucleotide polymorphism
- Citation
- International Journal of Environmental Research and Public Health, v.20, no.2
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- International Journal of Environmental Research and Public Health
- Volume
- 20
- Number
- 2
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62359
- DOI
- 10.3390/ijerph20021027
- ISSN
- 1661-7827
1660-4601
- Abstract
- Patients with peripheral arterial disease (PAD) are at a higher risk of developing postoperative complications. Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays an important role in atherosclerosis pathogenesis. In this study, the relationship between PAD and several single nucleotide polymorphisms (SNPs) of ALOX5AP (rs17216473, rs10507391, rs4769874, rs9551963, rs17222814, and rs7222842) was investigated in elderly patients undergoing general surgery. The medical records of 129 patients aged > 55 years who underwent elective general surgery between May 2018 and August 2019 were retrospectively reviewed. The A/A in rs17216473, A/A in rs10507391, G/G in rs4769874, and A/A in rs9551963 were calculated as 0 points and the rest as 1 point to define the genetic risk score. The prevalence of PAD tended to increase with higher genetic risk scores (patients had less ALOX5AP gene polymorphism of A/A in rs17216473, A/A in rs10507391, G/G in rs4769874, or A/A in rs9551963) (p = 0.005). Multivariate logistic regression analysis revealed that the genetic risk score (p = 0.009) and age (p = 0.007) were positively correlated with the prevalence of PAD. Genetic polymorphisms of ALOX5AP and age were associated with the prevalence of PAD in this study.
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Collections - 2. Clinical Science > Department of Anesthesiology and Pain Medicine > 1. Journal Articles
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