Use of prophylactic perioperative antibiotics for lumbar spinal fusions: A nationwide population-based cohort studyopen access
- Authors
- Ham, Chang Hwa; Kwon, Woo-Keun; Moon, Hong Joo; Kim, Joo Han; Park, Youn-Kwan; Hofstetter, Christoph P.
- Issue Date
- Mar-2023
- Publisher
- Elsevier BV
- Keywords
- Perioperative prophylactic antibiotics; Lumbar fusion; Population-based nationwide data; Cephalosporin; Vancomycin
- Citation
- Journal of Infection and Public Health, v.16, no.3, pp 354 - 360
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Infection and Public Health
- Volume
- 16
- Number
- 3
- Start Page
- 354
- End Page
- 360
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62460
- DOI
- 10.1016/j.jiph.2023.01.005
- ISSN
- 1876-0341
1876-035X
- Abstract
- Background
Perioperative prophylactic antibiotic (PPA) use in spine surgery is known to reduce the rate of surgical site infections. In the past decade, several evidence-based guidelines have been published and surveillance systems to monitor the proper use of antimicrobials had been adapted by many institutes.
Objective
To report the trends of PPA prescription in lumbar fusion surgeries nationwide in the Republic of Korea.
Methods
This is a nationwide registry study. Using the population-based data from the Republic of Korea provided by the Korean Health Insurance Review and Assessment Service, data of all lumbar spinal fusion surgeries performed between 2010 and 2018 in adult patients (age ≥19 years) were reviewed.
Results
The most frequently used antibiotics were first-generation cephalosporins, which accounted for 38.2 % of total PPA prescriptions and were prescribed in 58.96 % of lumbar fusion surgeries. A gradual increase in prescription trends was observed. The second most frequently used PPAs were second-generation cephalosporins, which showed decrease in use from 2016. The frequency of vancomycin prescriptions gradually increased over the observation period and showed an almost four-fold increase in 2018 compared to 2010. First- and second-generation cephalosporins were prescribed less frequently to patients with renal disease.
Conclusion
The pattern of PPA use has changed remarkably over the observation period. Furthermore, specific differences in PPA prescriptions were observed among patients with certain co-morbidities.
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- Appears in
Collections - 2. Clinical Science > Department of Neurosurgery > 1. Journal Articles
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