Childhood abuse and cortical gray matter volume in patients with major depressive disorder
- Authors
- Kim, Soo Young; An, Seong Joon; Han, Jong Hee; Kang, Youbin; Bae, Eun Bit; Tae, Woo-Suk; Ham, Byung-Joo; Han, Kyu-Man
- Issue Date
- Jan-2023
- Publisher
- Elsevier BV
- Keywords
- Major depressive disorder; Depression; Childhood abuse; Sexual abuse; Cortical volume; Magnetic resonance imaging
- Citation
- Psychiatry Research, v.319
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- Psychiatry Research
- Volume
- 319
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62462
- DOI
- 10.1016/j.psychres.2022.114990
- ISSN
- 0165-1781
- Abstract
- Childhood abuse is associated with brain structural alterations; however, few studies have investigated the association between specific types of childhood abuse and cortical volume in patients with major depressive disorder (MDD). We aimed to investigate the association between specific types of childhood abuse and gray matter volumes in patients with MDD. Seventy-five participants with MDD and 97 healthy controls (HCs) aged 19-64 years were included. Cortical gray matter volumes were compared between MDD and HC groups, and also compared according to exposure to each type of specific childhood abuse. Emotional, sexual, and physical childhood abuse were assessed using the 28-item Childhood Trauma Questionnaire. Patients with MDD showed a significantly decreased gray matter volume in the right anterior cingulate gyrus (ACG). Childhood sexual abuse (CSA) was associated with significantly decreased gray matter volume in the right middle occipital gyrus (MOG). In the post-hoc comparison of volumes of the right ACG and MOG, MDD patients with CSA had significantly smaller volumes in the right MOG than did MDD patients without CSA or HCs. The right MOG volume decrease could be a neuroimaging marker associated with CSA and morphological changes in the brain may be involved in the pathophysiology of MDD.
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Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
- 4. Research institute > Brain Convergence Research Center > 1. Journal Articles
- 4. Research institute > Medical Big-data Research Center > 1. Journal Articles
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