Developing Hemodynamic Valve Deterioration and Mortality in Aortic Valve Replacement
- Authors
- Kim, Hee Jung; Yang, Kyung-Sook; Kim, Joon Bum; Jung, Sung-Ho; Choo, Suk Jung; Chung, Cheol Hyun; Lee, Jae Won
- Issue Date
- May-2023
- Publisher
- Academic Press
- Keywords
- Aortic valve replacement; Bioprosthesis; Hemodynamic valve dysfunction
- Citation
- Journal of Surgical Research, v.285, pp 236 - 242
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Surgical Research
- Volume
- 285
- Start Page
- 236
- End Page
- 242
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62474
- DOI
- 10.1016/j.jss.2022.10.035
- ISSN
- 0022-4804
1095-8673
- Abstract
- Background
As life span increases, in patients having a bioprosthetic valve, the development of hemodynamic valve deterioration (HVD) is an important concern. We evaluated the association of developing HVD to survival in patients undergoing surgical aortic valve replacement (SAVR).
Methods
The individuals undergoing isolated SAVR and serial echocardiography exams (interval >30 d) were included in this study. HVD was defined as mean pressure gradient ≥ 20 mmHg, mean pressure gradient ≥10 mmHg higher than in the baseline exam, or more than moderate regurgitation on Doppler echocardiography (moderate and severe grade). A time-dependent Cox proportional hazard model was used for this study.
Results
A total of 631 patients were included. The mean age was 71.8 ± 6.1 y old (female: 53.6%). HVD was found in 259 patients (41%) during echocardiographic follow-up (mean 3.3 ± 3.0 y). Patient-prosthetic mismatch was found in 174 patients. One hundred and twenty-six patients died during follow-up (median 62.1 mo, interquartile range 31.1-96.8). The development of HVD was an independent risk factor for death during follow-up (P = 0.038, hazard ratio 1.46, 95% confidential interval: 1.02-2.08).
Conclusions
HVD was common after bioprosthetic SAVR during mid-term follow-up. Developing HVD, including moderate and severe grades, was associated with a poor survival rate compared with patients without HVD.
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- Appears in
Collections - 5. Others > Medical Science Research Management Center > 1. Journal Articles
- 2. Clinical Science > Department of Thoracic and Cardiovascular Surgery > 1. Journal Articles
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