Allogeneic Demineralized Dentin Matrix as rhBMP-2 Carrier: A Retrospective Clinical Study
- Authors
- Ku, Jeong-Kui; Kim, Young-Kyun; Huh, Jong-Ki; Um, In-Woong; Lee, Eui Seok; Kim, Chungyeul
- Issue Date
- Nov-2022
- Publisher
- Quintessence Publishing Company
- Keywords
- allogeneic; bone substitutes; demineralized dentin matrix; dental implant; rhBMP-2
- Citation
- International Journal of Oral and Maxillofacial Implants, v.37, no.6, pp 1138 - 1144
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- International Journal of Oral and Maxillofacial Implants
- Volume
- 37
- Number
- 6
- Start Page
- 1138
- End Page
- 1144
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62492
- DOI
- 10.11607/jomi.9692
- ISSN
- 0882-2786
1942-4434
- Abstract
- Purpose
To compare the clinical outcomes of autogenous and allogeneic demineralized dentin matrices loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2; auto- and allo-DDM/rhBMP-2) by measuring the buccal marginal bone resorption around dental implants.
Materials and Methods
This retrospective study included patients who underwent dental implant placement with auto-DDM/rhBMP-2 as the control group and allo- DDM/rhBMP-2 as the experimental group. The primary outcome was buccal marginal bone resorption on CBCT. The resorption was calculated during T0 (from surgery to prosthetic loading), T1 (during the first year after loading), and T2 (during the second year after loading). The secondary outcome was the histologic analysis of five specimens of each group, obtained during the prosthetic procedure.
Results
Among the 103 implants, 61 and 42 implants were placed with auto- and allo-DDM/rhBMP-2 matrices, respectively. The resorptions of all periods were similar between the groups (T0: 0.65 +/- 0.71 and 0.67 +/- 0.81 mm, T1: 0.55 +/- 0.60 and 0.59 +/- 0.81 mm, and T2: 0.29 +/- 0.45 and 0.20 +/- 0.30 mm with auto- and allo-DDM/rhBMP-2, respectively). The histologic and histomorphometric analysis revealed similar osteoinductive aspects and proportions of new bone between the groups.
Conclusion
Allo-DDM/rhBMP-2 showed comparable outcomes in terms of buccal marginal bone resorption to auto-DDM/rhBMP-2 during the second year after loading.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Pathology > 1. Journal Articles
- 2. Clinical Science > Department of Oral and Maxillofacial Surgery > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.