Independent effect of cardiometabolic syndromes and depression on dementia in Parkinson's disease: A 12-year longitudinal follow-up study of a nationwide cohort
- Authors
- Kang, Sung Hoon; Choi, Yunjin; Chung, Su Jin; Kim, Chi Kyung; Kim, Ji Hyun; Oh, Kyungmi; Yoon, Joon Shik; Cho, Geum Joon; Koh, Seong-Beom
- Issue Date
- Apr-2023
- Publisher
- Blackwell Publishing Inc.
- Keywords
- cardiometabolic syndromes; depression; incidence rate; Parkinson's disease dementia
- Citation
- European Journal of Neurology, v.30, no.4, pp 911 - 919
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- European Journal of Neurology
- Volume
- 30
- Number
- 4
- Start Page
- 911
- End Page
- 919
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62519
- DOI
- 10.1111/ene.15689
- ISSN
- 1351-5101
1468-1331
- Abstract
- Background
We aimed to investigate the incidence rate of Parkinson's disease dementia (PDD) according to age and disease duration by sex. Furthermore, we explored the effect of each cardiometabolic syndrome and depression on the incidence of PDD.
Methods
Using data from the Korean National Health Insurance Service, 79,622 patients with de novo Parkinson's disease (PD) aged ≥40 years between January 2002 and December 2010 were followed to December 2019. We analyzed the incidence of PDD according to age at PD diagnosis and disease duration. To determine cardiometabolic syndromes and depression that affected PDD, we used Fine and Gray competing regression after controlling for age and sex.
Results
During the 12.5-year follow-up period, the incidence of PDD increased with age at PD diagnosis (0.81–45.31 per 1000 person-years among those aged 40–44 and over 80 years, respectively) and longer disease duration (22.68 per 1000 person-years in 1–2 years to 34.16 per 1000 person-years in 15–16 years). Hypertension (subdistribution hazard ratio [SHR] = 1.11; 95% confidence interval [CI] 1.07–1.16), diabetes (SHR = 1.09; 95% CI 1.05–1.14), dyslipidemia (SHR = 1.15; 95% CI 1.11–1.20), and depression (SHR = 1.36; 95% CI 1.30–1.41) independently increased the risk for PDD.
Conclusions
Our findings provide insights into cardiometabolic syndromes as modifiable risk factors for incident PDD. Furthermore, our results will help in designing public health policies with respect to controlling cardiometabolic syndromes and depression to prevent incident PDD in patients with PD.
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- Appears in
Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
- 2. Clinical Science > Department of Physical Medicine and Rehabilitation > 1. Journal Articles
- 2. Clinical Science > Department of Neurology > 1. Journal Articles
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