The clinical impact of donor against recipient HLA one way mismatch on the occurrence of graft versus host disease in liver transplantationopen access
- Authors
- Kim, Sang Jin; Park, Sunghae; Rhu, Jinsoo; Kim, Jong Man; Choi, Gyu-Seong; Joh, Jae-Won
- Issue Date
- Nov-2022
- Publisher
- Nature Publishing Group
- Citation
- Scientific Reports, v.12, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- Scientific Reports
- Volume
- 12
- Number
- 1
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62548
- DOI
- 10.1038/s41598-022-24778-2
- ISSN
- 2045-2322
- Abstract
- Graft versus host disease (GVHD) after liver transplantation (LT) is a rare, fatal disease. This study aimed to evaluate the risk factors of GVHD after LT including the human leukocyte antigen (HLA) donor-recipient relationship after LT. LT recipients, who underwent HLA typing together with donors, were included in the study. The donor against recipient (D -> R) one-way mismatch of HLA loci was evaluated. HLA relationships, along with basic characteristics, were analyzed as variable factors of GVHD, graft survival, and patient survival. A total of 994 living donor LT (LDLT) and 393 deceased donor LT (DDLT) patients were included. Nine patients had suffered GVHD, four LDLT with D -> R one-way at three loci, one LDLT without D -> R one-way at three loci, and four DDLT without D -> R one-way at three loci. Four (57.1%) of seven LDLT patients, with D -> R one-way mismatch at three loci, developed GVHD. D -> R one-way mismatch at three loci was related to high GVHD incidence (HR 787, p<0.001, multivariate). D -> R one-way mismatch at three loci was related to graft failure and patient death (HR 9.90, p=0.020 and HR 12.8, p<0.001, respectively, multivariate). Only one GVHD without D -> R one-way mismatch at three loci, survived despite receiving multiple modalities including tumor necrosis factor-alpha inhibitors. D -> R one-way mismatch at three loci was significantly related to GVHD incidence after LT.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Hepato-Biliary-Pancreatic Surgery > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.