High-resolution pancreatic computed tomography for assessing pancreatic ductal adenocarcinoma resectability: a multicenter prospective study
- Authors
- Lee, Dong Ho; Ha, Hong Il; Jang, Jin-Young; Lee, Jung Woo; Choi, Jin-Young; Bang, Seungmin; Lee, Chang Hee; Kim, Wan Bae; Lee, Seung Soo; Kim, Song Cheol; Kang, Bo-Kyeong; Lee, Jeong Min
- Issue Date
- Sep-2023
- Publisher
- Springer Verlag
- Keywords
- Carcinoma; pancreatic ductal; Multidetector computed tomography; Margins of excision
- Citation
- European Radiology, v.33, no.9, pp 5965 - 5975
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- European Radiology
- Volume
- 33
- Number
- 9
- Start Page
- 5965
- End Page
- 5975
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62929
- DOI
- 10.1007/s00330-023-09584-2
- ISSN
- 0938-7994
1432-1084
- Abstract
- Objective
This prospective multicenter study aimed to evaluate the diagnostic performance of 80-kVp thin-section pancreatic CT in determining pancreatic ductal adenocarcinoma (PDAC) resectability according to the recent National Comprehensive Cancer Network (NCCN) guidelines.
Methods
We prospectively enrolled surgical resection candidates for PDAC from six tertiary referral hospitals (study identifier: NCT03895177). All participants underwent pancreatic CT using 80 kVp tube voltage with 1-mm reconstruction interval. The local resectability was prospectively evaluated using NCCN guidelines at each center and classified into three categories: resectable, borderline resectable, and unresectable.
Results
A total of 138 patients were enrolled; among them, 60 patients underwent neoadjuvant therapy. R0 resection was achieved in 103 patients (74.6%). The R0 resection rates were 88.7% (47/53), 52.4% (11/21), and 0.0% (0/4) for resectable, borderline resectable, and unresectable disease, respectively, in 78 patients who underwent upfront surgery. Meanwhile, the rates were 90.9% (20/22), 76.7% (23/30), and 25.0% (2/8) for resectable, borderline resectable, and unresectable PDAC, respectively, in patients who received neoadjuvant therapy. The area under curve of high-resolution CT in predicting R0 resection was 0.784, with sensitivity, specificity, and accuracy of 87.4% (90/103), 48.6% (17/35), and 77.5% (107/138), respectively. Tumor response was significantly associated with the R0 resection after neoadjuvant therapy (odds ratio [OR] = 38.99, p = 0.016).
Conclusion
An 80-kVp thin-section pancreatic CT has excellent diagnostic performance in assessing PDAC resectability, enabling R0 resection rates of 88.7% and 90.9% for patients with resectable PDAC who underwent upfront surgery and patients with resectable PDAC after neoadjuvant therapy, respectively.
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Collections - 2. Clinical Science > Department of Hepato-Biliary-Pancreatic Surgery > 1. Journal Articles
- 2. Clinical Science > Department of Radiology > 1. Journal Articles
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