Feasibility and Efficacy of Morning Light Therapy for Adults with Insomnia: A Pilot, Randomized, Open-Label, Two-Arm Studyopen access
- Authors
- Yoon, Jihyun; Heo, Seok-Jae; Lee, Hyangkyu; Sul, Eun Gyeong; Han, Tae-Hwa; Kwon, Yu-Jin
- Issue Date
- Jun-2023
- Publisher
- MDPI
- Keywords
- light therapy; sleep disorder; daytime sleepiness; circadian rhythm; clock gene
- Citation
- Medicina (Kaunas, Lithuania), v.59, no.6
- Indexed
- SCIE
SCOPUS
- Journal Title
- Medicina (Kaunas, Lithuania)
- Volume
- 59
- Number
- 6
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62957
- DOI
- 10.20944/preprints202304.0335.v1
- ISSN
- 1010-660X
1648-9144
- Abstract
- Background and Objectives
Light therapy (LT) is used as an adjunctive treatment for sleep problems. This study evaluates the impact of LT on sleep quality and sleep-related parameters in patients with sleep disorders.
Materials and Methods
We performed a pilot randomized, open-label clinical trial. Fourteen patients aged 20–60 years with sleep disorders for more than three months were randomized into the control and LT groups (1:1 ratio). The LT group was instructed to use a device that provides bright LT (6000 K, 380 lux, wavelength 480 nm) for at least 25 minutes before 09:00 am for two weeks. A self-reported questionnaire was used to evaluate circadian preference, mood, and sleep-related parameters. We analyzed serum cortisol levels and clock genes expression.
Results
The Epworth Sleepiness Scale (ESS), insomnia severity index, and Pittsburgh Sleep Quality index were significantly improved within the LT group only after the two-week period. When comparing the two groups, only the change in ESS significant was significant (mean difference; control: -0.14 vs LT: -1.43, p=0.021) after adjusting for baseline characteristics. There were no significant differences in serum cortisol or clock genes expression.
Conclusions
LT can improve daytime sleepiness in patients with sleep disorders; however, further well-designed studies are warranted to confirm its efficacy.
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Collections - 2. Clinical Science > Department of Family Medicine > 1. Journal Articles
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