Gray and white matter abnormalities in major depressive disorder patients and its associations with childhood adversity
- Authors
- Kang, Wooyoung; Kang, Youbin; Kim, Aram; Kim, Hyeyoung; Han, Kyu-Man; Ham, Byung-Joo
- Issue Date
- Jun-2023
- Publisher
- Elsevier BV
- Keywords
- Child adversity; Gray matter abnormalities; White matter abnormalities; Major depressive disorder; Traumatic brain
- Citation
- Journal of Affective Disorders, v.330, pp 16 - 23
- Pages
- 8
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- Journal of Affective Disorders
- Volume
- 330
- Start Page
- 16
- End Page
- 23
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62998
- DOI
- 10.1016/j.jad.2023.02.145
- ISSN
- 0165-0327
1573-2517
- Abstract
- Objective
Early life stress of childhood adversity (CA) may result in major depressive disorder (MDD) by sensitizing individuals to proximal stressors in life events. The neurobiological changes that underlie adult depression may result from the absence of proper care and supervision of caregivers. We aimed to find both gray and white matter abnormalities in MDD patients, who reported the experiences of CA.
Methods
The present study examined cortical alterations in 54 patients with MDD and 167 healthy controls (HCs) using voxel-based morphology and fractional anisotropy (FA) tract-based spatial statistics (TBSS). Both patients and HCs were administered the self-questionnaire clinical scale (the Korean translation of the Childhood Trauma Questionnaire CTQsingle bondK). Pearson's correlation analysis was performed to find the associations between FA and CTQsingle bondK.
Results
The MDD group showed a significant decrease in gray matter (GM) in the left rectus at both the cluster and peak levels after family-wise error correction. The TBSS results showed significantly reduced FA in widespread regions, including the corpus callosum (CC), superior corona radiata, cingulate gyrus, and superior longitudinal fasciculus. The CA was negatively correlated with the FA in CC and crossing pontine tract.
Conclusion
Our findings demonstrated GM atrophy and white matter (WM) connectivity changes in patients with MDD. The major findings of the widespread FA reduction in WM provided the evidence of brain alterations in MDD. We further propose that the WM would be vulnerable to emotional, physical, and sexual abuse in early childhood during the brain development.
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- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
- 4. Research institute > Institute of Human Behavior and Genetics > 1. Journal Articles
- 2. Clinical Science > Department of Radiology > 1. Journal Articles
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