Multidetector Computed Tomography Imaging Features of Inflammatory Myofibroblastic Tumors of the Gastrointestinal Tract in Adults: Radiological, Histopathological, and Immunohistochemical Features
- Authors
- Choi, In Young; Yeom, Suk Keu; Park, Beom Jin; Sung, Deuk Jae; Kim, Min Ju; Han, Na Yeon; Park, Yang Shin; Cha, Sang Hoon; Kim, So Yeon; Choi, Jung -Woo
- Issue Date
- Jan-2023
- Publisher
- Kowsar
- Keywords
- Stomach; Intestines; Multidetector Computed Tomography; Neoplasms; Granuloma
- Citation
- Iranian Journal of Radiology, v.20, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- Iranian Journal of Radiology
- Volume
- 20
- Number
- 1
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63014
- DOI
- 10.5812/ijr-129661
- ISSN
- 1735-1065
2008-2711
- Abstract
- Background
Inflammatory myofibroblastic tumors (IMTs) of the gastrointestinal (GI) tract are rare phenomena, and the computed tomography (CT) findings of GI IMTs are not well-established.
Objectives
To describe the characteristics of CT scans, pathological specimens, and histological subtypes of GI IMTs in adults.
Patients and Methods
The multidetector computed tomography (MDCT) scans of 11 adult patients (8 males, 3 females; age range, 19 - 76 years) with pathologically proven GI tract IMTs (stomach, small bowel, and colon) were retrospectively evaluated by two abdominal radiologists. The radiological features of IMTs were investigated. The imaging features were correlated with three microscopic IMT subtypes (myxoid vascular, spindle cell, and hypocellular fibrous). Immunohistochemistry was also performed on the specimens, including smooth muscle actin (SMA), vimentin, desmin, S-100, and anaplastic lymphoma kinase.
Results
The tumor size ranged from 1.4 to 15 cm (mean, 5.7 cm). Two growth patterns were classified, namely, wall-thickening (n = 3) and solitary mass-forming (n = 8) patterns; each pattern was matched with a characteristic pathological subtype. All solitary, well-circumscribed masses corresponded to the spindle cell type. Low-attenuation wall thickening with perienteric infiltration was observed in three patients with a wall-thickening pattern. All solitary, well-circumscribed masses (n = 8) showed homogeneous enhancement with variable internal low attenuation, correlated with cystic degeneration, necrosis, myxoid change (n = 6), and hemorrhagic necrosis (n = 2). No patient showed bowel obstruction, while one patient showed regional lymphadenopathy. Immunophenotypes were not correlated with any growth pattern or histological subtype.
Conclusion
The GI IMTs can be classified into two patterns, including wall-thickening and well-circumscribed masses, each matched with a characteristic pathological subtype, which can help explain the tumor behavior. Concomitant CT findings may also provide diagnostic clues for IMT.
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Collections - 2. Clinical Science > Department of Pathology > 1. Journal Articles
- 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
- 2. Clinical Science > Department of Radiology > 1. Journal Articles
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