Childhood Sexual Abuse and Cortical Thinning in Adults With Major Depressive Disorder
- Authors
- Kim, Jinyi; Lee, Chanju; Kang, Youbin; Kang, Wooyoung; Kim, Aram; Tae, Woo-Suk; Ham, Byung-Joo; Chang, Jisoon; Han, Kyu-Man
- Issue Date
- Mar-2023
- Publisher
- 대한신경정신의학회
- Keywords
- Childhood trauma; Sexual abuse; Depression; Major depressive disorder; Prefrontal cortex; Magnetic resonance imaging
- Citation
- PSYCHIATRY INVESTIGATION, v.20, no.3, pp 255 - 261
- Pages
- 7
- Indexed
- SCIE
SSCI
SCOPUS
KCI
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 20
- Number
- 3
- Start Page
- 255
- End Page
- 261
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63413
- DOI
- 10.30773/pi.2022.0314
- ISSN
- 1738-3684
1976-3026
- Abstract
- Objective
A growing body of evidence reports on the effect of different types of childhood abuse on the structural and functional architecture of the brain. In the present study, we aimed to investigate the differences in cortical thickness according to specific types of childhood abuse between patients with major depressive disorder (MDD) and healthy controls (HCs).
Methods
A total of 61 patients with MDD and 98 HCs were included in this study. All participants underwent T1-weighted magnetic resonance imaging, and the occurrence of childhood abuse was assessed using the Childhood Trauma Questionnaire. We investigated the association between whole-brain cortical thickness and exposure to any type of childhood abuse and specific type of childhood abuse in the total sample using the FreeSurfer software.
Results
No significant difference was reported in the cortical thickness between the MDD and HC groups nor between the “any abuse” and “no abuse” groups. Compared to no exposure to childhood sexual abuse (CSA), exposure to CSA was significantly associated with cortical thinning in the left rostral middle frontal gyrus (p=0.00020), left (p=0.00240), right fusiform gyri (p=0.00599), and right supramarginal gyrus (p=0.00679).
Conclusion
Exposure to CSA may lead to cortical thinning of the dorsolateral prefrontal cortex, which is deeply involved in emotion regulation, to a greater extent than other types of childhood abuse.
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- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
- 4. Research institute > Brain Convergence Research Center > 1. Journal Articles
- 4. Research institute > Institute of Human Behavior and Genetics > 1. Journal Articles
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