CAGE-B and SAGE-B models better predict the hepatitis B virus-related hepatocellular carcinoma after 5-year entecavir treatment than PAGE-B
- Authors
- Chon, Hye Yeon; Lee, Han Ah; Park, Soo Young; Seo, Yeon Seok; Kim, Sang Gyune; Lee, Chang Hun; Lee, Tae Hee; Ahn, Sang Hoon; Wong, Vincent Wai-Sun; Yip, Terry Cheuk-Fung; Liang, Lilian Yan; Kim, In Hee; Wong, Grace Lai-Hung; Kim, Seung Up
- Issue Date
- Feb-2023
- Publisher
- Blackwell Pub. Asia
- Keywords
- CAGE-B; hepatitis B; PAGE-B; risk prediction; SAGE-B
- Citation
- Journal of Digestive Diseases, v.24, no.2, pp 113 - 121
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Digestive Diseases
- Volume
- 24
- Number
- 2
- Start Page
- 113
- End Page
- 121
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63523
- DOI
- 10.1111/1751-2980.13172
- ISSN
- 1751-2972
1751-2980
- Abstract
- Objectives
The PAGE-B model consists of variables at the initiation of antiviral therapy (AVT), whereas the SAGE-B and CAGE-B models consist of variables after 5 years of AVT. We aimed to compare the predictive accuracy of three risk prediction models for hepatocellular carcinoma (HCC) development after 5 years of AVT in patients with chronic hepatitis B (CHB).
Methods
A total of 1335 patients who initiated entecavir (ETV) treatment between 2006 and 2011 and were followed up for more than 5 years were enrolled in the study.
Results
At ETV initiation, the median age was 49 years and the median score of the PAGE-B model was 14. After 5 years of ETV treatment, the median SAGE-B and CAGE-B scores were 6 and 6. During the study period, 93 (7.0%) patients developed HCC after 5-year treatment. In multivariate analysis, PAGE-B (hazard ratio [HR] 1.151, 95% confidence interval [CI] 1.087–1.219), SAGE-B (HR 1.340, 95% CI 1.228–1.463), and CAGE-B (HR 1.327, 95% CI 1.223–1.440) models independently predicted HCC development after 5 years of treatment (all P < 0.001). The high-risk groups of the three risk prediction models showed a significantly higher risk of HCC development compared to the medium- and low-risk groups (both P < 0.05). The AUROC of the SAGE-B (0.772–0.844) and CAGE-B (0.785–0.838) models was significantly higher than those of the PAGE-B model (0.696–0.745) in predicting HCC development after 5 years of treatment (both P < 0.05).
Conclusion
The SAGE-B and CAGE-B models might be better than the PAGE-B model in predicting HCC development after 5 years of ETV treatment.
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Collections - 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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