Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male miceopen access
- Authors
- Yang, Soo Hyun; Yang, Esther; Lee, Jaekwang; Kim, Jin Yong; Yoo, Hyeijung; Park, Hyung Sun; Jung, Jin Taek; Lee, Dongmin; Chun, Sungkun; Jo, Yong Sang; Pyeon, Gyeong Hee; Park, Jae-Yong; Lee, Hyun Woo; Kim, Hyun
- Issue Date
- Apr-2023
- Publisher
- Nature Publishing Group
- Citation
- Nature Communications, v.14, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- Nature Communications
- Volume
- 14
- Number
- 1
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63536
- DOI
- 10.1038/s41467-023-38180-7
- ISSN
- 2041-1723
2041-1723
- Abstract
- Stress management is necessary for vertebrate survival. Chronic stress drives depression by excitation of the lateral habenula (LHb), which silences dopaminergic neurons in the ventral tegmental area (VTA) via GABAergic neuronal projection from the rostromedial tegmental nucleus (RMTg). However, the effect of acute stress on this LHb-RMTg-VTA pathway is not clearly understood. Here, we used fluorescent in situ hybridisation and in vivo electrophysiology in mice to show that LHb aromatic l-amino acid decarboxylase-expressing neurons (D-neurons) are activated by acute stressors and suppress RMTg GABAergic neurons via trace aminergic signalling, thus activating VTA dopaminergic neurons. We show that the LHb regulates RMTg GABAergic neurons biphasically under acute stress. This study, carried out on male mice, has elucidated a molecular mechanism in the efferent LHb-RMTg-VTA pathway whereby trace aminergic signalling enables the brain to manage acute stress by preventing the hypoactivity of VTA dopaminergic neurons. Effective stress regulation is essential for the survival of vertebrates. Here, the authors show that the lateral habenula trace aminergic signalling activates the mesolimbic pathway through suppressing the rostromedial tegmental nucleus to manage stress.
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- Appears in
Collections - 3. Graduate School > Graduate School > 1. Journal Articles
- 1. Basic Science > Department of Anatomy > 1. Journal Articles
- 4. Research institute > Institute of Human Genetics > 1. Journal Articles
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