Development and validation of equation for cardiorespiratory fitness in patients with heart failure with preserved ejection fractionopen access
- Authors
- Battumur, Byambakhand; Lee, Ji Eun; Park, Soo Hyung; Choi, You-Jung; Kang, Dong Oh; Park, Eun Jin; Kim, Ji Bak; Choi, Jah Yeon; Roh, Seung Young; Na, Jin Oh; Choi, Cheol Ung; Kim, Jin Won; Rha, Seung Woon; Park, Chang Gyu; Kim, Eung Ju
- Issue Date
- Jul-2023
- Publisher
- 대한내과학회
- Keywords
- Heart failure; Cardiorespiratory fitness; Oxygen consumption; Validation study; Metabolic equivalent
- Citation
- The Korean Journal of Internal Medicine, v.38, no.4, pp 514 - 525
- Pages
- 12
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- The Korean Journal of Internal Medicine
- Volume
- 38
- Number
- 4
- Start Page
- 514
- End Page
- 525
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63562
- DOI
- 10.3904/kjim.2022.375
- ISSN
- 1226-3303
2005-6648
- Abstract
- Background/Aims
Cardiorespiratory fitness (CRF), as measured by maximal oxygen consumption (VO2max), is an important independent predictive factor of cardiovascular outcomes in patients with heart failure (HF). However, it is unclear whether conventional equations for estimating CRF are applicable to patients with HF with preserved ejection fraction (HFpEF).
Methods
This study included 521 patients with HFpEF (EF ≥ 50%) whose CRF was directly measured by cardiopulmonary exercise test using a treadmill. We developed a new equation (Kor-HFpEF) for half of the patients in the HFpEF cohort (group A, n = 253) and validated it for the remaining half (group B, n = 268). The accuracy of the Kor-HFpEF equation was compared to that of the other equations in the validation group.
Results
In the total HFpEF cohort, the directly measured VO2max was significantly overestimated by the FRIEND and ACSM equations (p < 0.001) and underestimated by the FRIEND-HF equation (p <0.001) (direct 21.2 ± 5.9 mL/kg/min; FRIEND 29.1 ± 11.8 mL/kg/min; ACSM 32.5 ± 13.4 mL/kg/min; FRIEND-HF 14.1 ± 4.9 mL/kg/min). However, the VO2max estimated by the Kor-HFpEF equation (21.3 ± 4.6 mL/kg/min) was similar to the directly measured VO2max (21.7 ± 5.9 mL/kg/min, p = 0.124), whereas the VO2max estimated by the other three equations was still significantly different from the directly measured VO2max in group B (all p < 0.001).
Conclusions
Traditional equations used to estimate VO2max were not applicable to patients with HFpEF. We developed and validated a new Kor-HFpEF equation for these patients, which had a high accuracy.
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- Appears in
Collections - 4. Research institute > Cardiovascular Research Institute > 1. Journal Articles
- 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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