Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafishopen access
- Authors
- Kim, Yeonhwa; Kim, Seong Soon; Park, Byeong Heon; Hwang, Kyu-Seok; Bae, Myung Ae; Cho, Sung-Hee; Kim, Suhyun; Park, Hae-Chul
- Issue Date
- Jun-2023
- Publisher
- MDPI AG
- Keywords
- zebrafish; bisphenol F; locomotion; motor neuron; myelination; neurochemicals
- Citation
- Toxics, v.11, no.6
- Indexed
- SCIE
SCOPUS
- Journal Title
- Toxics
- Volume
- 11
- Number
- 6
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63572
- DOI
- 10.3390/toxics11060477
- ISSN
- 2305-6304
- Abstract
- Bisphenol F (BPF; 4,4 & PRIME;-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.
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Collections - 3. Graduate School > Biomedical Research Center > 1. Journal Articles
- 4. Research institute > Zebrafish Translational Medical Research Center > 1. Journal Articles
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