구강 작열감 증후군에서 Pregabalin의 치료 효과Effectiveness of Pregabalin in Treatment of Burning Mouth Syndrome
- Other Titles
- Effectiveness of Pregabalin in Treatment of Burning Mouth Syndrome
- Authors
- 최석열; 최현석; 조재구
- Issue Date
- Nov-2022
- Publisher
- 대한이비인후과학회
- Keywords
- Burning mouth syndrome; Neuropathic pain; Pregabalin
- Citation
- Korean Journal of Otorhinolaryngology Head and Neck Surgery, v.65, no.11, pp 692 - 696
- Pages
- 5
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Otorhinolaryngology Head and Neck Surgery
- Volume
- 65
- Number
- 11
- Start Page
- 692
- End Page
- 696
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63687
- DOI
- 10.3342/kjorl-hns.2022.00472
- ISSN
- 2092-5859
2092-6529
- Abstract
- Background and Objectives
Burning mouth syndrome (BMS) is a chronic pain disorder involving a burning sensation of the oral cavity without any identifiable oral lesion. According to the recent studies, the pathogenesis of BMS is presumed to be caused by a neuropathic condition. Gabapentin and pregabalin have been used for various neuropathic pains, but pregabalin has several pharmacokinetic advantages over gabapentin. To our best knowledge, there are no recent studies reported on the administration of pregabalin in treating BMS in Korea. Therefore, in this study, we investigated the therapeutic effect of pregabalin in treating BMS.
Subjects and Method
We chose as candidates 33 patients diagnosed as BMS and took pregabalin for more than four weeks. Pregabalin was administered at 75 mg once a day for 2 to 4 weeks at first, and then the dose was modified depending on whether or not symptoms improved. Effectiveness of treatment was evaluated in the way that the patients subjectively answered whether or not symptoms were improved.
Results
A total of 21 (63.6%) out of 33 patients were responsive to the treatment. Among those, at the last follow-up, 8 patients (38.1%) showed slight improvement, and 13 patients (61.9%) showed mostly improvement or disappearance of symptoms. The average time interval from starting pregabalin to the first symptom improvement was 50.1 days, and most patients showed symptom improvement within 8 weeks.
Conclusion
This study concludes that pregabalin can be added as a meaningful option in the treatment of BMS. The additional double-blind clinical study should be followed to further prove the effectiveness of pregabalin.
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Collections - 2. Clinical Science > Department of Otorhinolaryngology-Head and Neck Surgery > 1. Journal Articles
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