한국에서의 단일 병변 광선 각화증 환자에 있어 국소 5-Fluorouracil 도포, 국소 Imiquimod 도포와냉동외과술의 치료 효용성 비교에 관한 연구Therapeutic Efficacy of Topical 5-Fluorouracil vs. Topical Imiquimod vs. Cryosurgery for Single-Lesion Actinic Keratosis in Korea
- Other Titles
- Therapeutic Efficacy of Topical 5-Fluorouracil vs. Topical Imiquimod vs. Cryosurgery for Single-Lesion Actinic Keratosis in Korea
- Authors
- 박성진; 김윤재; 조준혁; 김대현; 안효현; 서수홍
- Issue Date
- Jan-2023
- Publisher
- 대한피부과학회
- Keywords
- Actinic keratosis; Cryosurgery; Fluorouracil; Imiquimod
- Citation
- Korean Journal of Dermatology, v.61, no.1, pp 29 - 35
- Pages
- 7
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Dermatology
- Volume
- 61
- Number
- 1
- Start Page
- 29
- End Page
- 35
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63709
- ISSN
- 0494-4739
- Abstract
- Background
Actinic keratosis (AK) is a common precancerous cutaneous lesion. There are various AK treatment methods; however, no specific method is considered superior. Most existing studies on AK treatment are Caucasian-based and include patients with multiple lesions.
Objective
This study aimed to compare the treatment duration, financial costs, and success rates of topically applied 5% 5-fluorouracil (5-FU) solution, 5% imiquimod (IMIQ) cream, and cryosurgery in the treatment of histologically proven single-lesion AK in Korean patients.
Methods
We retrospectively reviewed the medical records of patients with single-lesion AK at a single Korean center from January 2018 to February 2021. Each patient was treated using the three aforementioned local treatments.
Results
The study included 58 patients. Nineteen of 23 (82.6%), 27 of 27 (100%), and eight of eight patients (100%) were successfully treated after topical 5-FU, topical IMIQ, and cryosurgery, respectively. Further analysis on treatment success by subgroup revealed the following: mean number of outpatient visits, 3.78 vs. 4.41 vs. 3.75; mean treatment duration, 5.79 vs. 6.00 vs. 9.38 weeks; and mean total treatment cost, 79,380 vs. 170,023 vs. 173,116 won; for the 5-FU, IMIQ, and cryosurgery subgroups, respectively. The total treatment cost was significantly different among the subgroups (p≤0.001).
Conclusion
Topical IMIQ and cryosurgery were superior in terms of treatment efficacy, but considering its low cost, 5-FU may also be a reasonable option. Hence, an individualized approach to treating localized AK should be taken.
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Collections - 2. Clinical Science > Department of Dermatology > 1. Journal Articles
- 3. Graduate School > Graduate School > 1. Journal Articles
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