Over-expression of Long Non-coding RNA Urothelial Cancer- associated 1 as a Predictive Marker for Prostate Cancer
- Authors
- Lee, Yoo jin; Kang, Sung gu; Kim, Chul hwan
- Issue Date
- Jul-2023
- Publisher
- International Institute of Anticancer Research
- Keywords
- Long non-coding RNA; urothelial cancer-associated 1; prostate cancer; in-situ hybridization; array-based quantitative polymerase chain reaction
- Citation
- In Vivo, v.37, no.4, pp 1511 - 1516
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- In Vivo
- Volume
- 37
- Number
- 4
- Start Page
- 1511
- End Page
- 1516
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63857
- DOI
- 10.21873/invivo.13236
- ISSN
- 0258-851X
1791-7549
- Abstract
- Background/Aim: To determine the expression of long non-coding RNA urothelial cancer-associated 1 (UCA1) by performing array-based quantitative polymerase chain reaction (PCR) and to identify the clinicopathological significance of UCA1 expression in prostate cancer using in situ hybridization (ISH) of surgically resected specimens. Materials and Methods: Array-based quantitative PCR was performed using 10 pairs of fresh malignant (prostate cancer) and normal tissue samples to determine UCA1 expression. Single-color RNA ISH of surgically resected prostate cancer specimens was performed using 70 formalinfixed, paraffin-embedded tissue specimens to examine the clinicopathological significance of UCA1. Results: Prostate cancer tissues exhibited higher levels of UCA1 expression than paired benign tissues. Furthermore, a correlation between high UCA1 expression and unfavourable clinicopathological characteristics, including advanced pathologic T stage, extraprostatic extension, presence of Gleason pattern 5, and involvement of the resection margins was observed. Notably, increased UCA1 expression significantly correlated with high- or very-high-risk patients, as defined by the 2023 National Comprehensive Cancer Network guidelines. Conclusion: UCA1 could be used as a novel diagnostic and prognostic biomarker for establishing an effective treatment protocol for prostate cancer.
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- Appears in
Collections - 2. Clinical Science > Department of Urology > 1. Journal Articles
- 2. Clinical Science > Department of Pathology > 1. Journal Articles
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