Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6
- Authors
- Kim, Jungryun; Jangili, Paramesh; Kim, Jeongah; Lucia, Stephani Edwina; Ryu, Jae Ryun; Prasad, Renuka; Zi, Soyu; Kim, Pilhan; Sun, Woong; Kim, Jong Seung
- Issue Date
- Aug-2023
- Publisher
- Royal Society of Chemistry
- Citation
- Chemical Communications, v.59, no.67, pp 10109 - 10112
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- Chemical Communications
- Volume
- 59
- Number
- 67
- Start Page
- 10109
- End Page
- 10112
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63944
- DOI
- 10.1039/d3cc03259k
- ISSN
- 1359-7345
1364-548X
- Abstract
- Despite the apparent copious fluorescent probes targeting mitochondria, the development of low cytotoxic probes is still needed for improving validation of mitochondrial function assessment. Herein, we report a novel cyanine-based NIR fluorescent probe, T2, which selectively targets mitochondria with significantly low toxicity by modulating the intracellular redox status. Additionally, T2 inhibits oxidative stress-induced cell death in cortical neurons. This study provides new insight into developing low-toxic mitochondrial imaging agents by regulating redox homeostasis.
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- Appears in
Collections - 1. Basic Science > Department of Anatomy > 1. Journal Articles
- 3. Graduate School > Graduate School > 1. Journal Articles
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