Spexin-based galanin receptor 2 agonist improves renal injury in mice with type 2 diabetesopen access
- Authors
- Cha, Jin Joo; Park, Boo Yeon; Yoon, Sung Gi; Park, Hye Jin; Yoo, Ji Ae; Ghee, Jung Yeon; Cha, Dae Ryong; Seong, Jae Young; Kang, Young Sun
- Issue Date
- Dec-2023
- Publisher
- 한국통합생물학회
- Keywords
- Spexin; Galanin receptor 2 agonist; Diabetic nephropathy
- Citation
- Animal Cells and Systems, v.27, no.1, pp 187 - 196
- Pages
- 10
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Animal Cells and Systems
- Volume
- 27
- Number
- 1
- Start Page
- 187
- End Page
- 196
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64143
- DOI
- 10.1080/19768354.2023.2263067
- ISSN
- 1976-8354
2151-2485
- Abstract
- The spexin-based GALR2 agonist (NS200) is a novel drug, which has shown antidepressant and anxiolytic action in a recent experimental study. In this study, we investigated the effects of NS200 on renal injury in an animal model of type 2 diabetes. Eight-week-old diabetic db/db mice were administered NS200 for 12 weeks. NS200 was intraperitoneally administered at a dose of 1.0 mg/kg/day. Metabolic parameters and structural and molecular changes in the kidneys were compared among the three groups: non-diabetic db/m control, db/db mice, and NS200-treated db/db mice. In db/db mice, NS200 administration did not impact the body weight, food and water intake, urinary volume, fasting blood glucose level, or HbA1c levels. Insulin and glucose tolerance were also unaffected by NS200 treatment. However, NS200 improved urinary albumin excretion and glomerulosclerosis in diabetic kidneys. Activation of TGF beta 1 and insulin signaling pathways, such as PI3 K /AKT/ERK, were inhibited by NS200. In conclusion, a spexin-based GALR2 agonist attenuated diabetic nephropathy by alleviating renal fibrosis in mice with type 2 diabetes. Spexin-based GALR2 agonists have considerable potential as novel treatment agents in diabetic nephropathy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 3. Graduate School > Biomedical Research Center > 1. Journal Articles
- 2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.